Low-level laser therapy modulates musculoskeletal loss in a skin burn model in rats

Low-level laser therapy modulates musculoskeletal loss in a skin burn model in rats

Author Martins, Francielle Google Scholar
Renno, Ana Claudia Muniz Autor UNIFESP Google Scholar
De Oliveira, Flavia Autor UNIFESP Google Scholar
Minatel, Natália Peruchi Google Scholar
Bortolin, Jeferson André Google Scholar
Quintana, Hananiah Tardivo Google Scholar
Aveiro, Mariana Chaves Autor UNIFESP Google Scholar
Institution Ministry of Science, Technology and Inovation National Council of Scientific and Technological Development Institutional Program for Scientific Initiation
Universidade Federal de São Paulo (UNIFESP)
Abstract PURPOSE: To investigate the effectiveness of low-level laser therapy (LLLT) on gastrocnemius muscle morphology and Myod imunoexpression in a model of dorsal burn in rats. METHODS: Sixteen male Wistar rats were distributed into two groups: control group (CG): rats submitted to scald burn injury without treatment and laser treated group (LG): rats submitted to scald burn injury and treated with laser therapy. Fourteen days post-surgery, gastrocnemius muscle was evaluated being the specimens stained with HE and morphometric data was evaluated. MyoD expression was assessed by immunohistochemistry. RESULTS: The results showed that laser treated animals presented more organized tissue morphology compared to the non-treated animals, with a higher number of nucleus in the fibers. Also, the cross sectional area of the fibers and the MyoD immunoexpression in the laser treated groups was higher. CONCLUSION: Low-level laser therapy had positive effects on gastrocnemius muscle, improving tissue muscle morphology, increasing cross sectional area and MyoD immunoexpression.
Keywords Burns
Laser Therapy, Low-Level
MyoD Protein
Rats
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2015-02-01
Published in Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 30, n. 2, p. 94-99, 2015.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extent 94-99
Origin http://dx.doi.org/10.1590/S0102-86502015002000002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000350333000002
SciELO ID S0102-86502015000200094 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8793

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