Lymphocyte subsets in human immunodeficiency virus-unexposed Brazilian individuals from birth to adulthood

Lymphocyte subsets in human immunodeficiency virus-unexposed Brazilian individuals from birth to adulthood

Author Moraes-Pinto, Maria Isabel de Autor UNIFESP Google Scholar
Ono, Erika Autor UNIFESP Google Scholar
Santos-Valente, Elisangela Calheiro dos Autor UNIFESP Google Scholar
Almeida, Liziane C Google Scholar
Andrade, Paula Rosemberg de Google Scholar
Dinelli, Maria Isabel Saraiva Autor UNIFESP Google Scholar
Dos Santos, Amelia Miyashiro Autor UNIFESP Google Scholar
Salomão, Reinaldo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Centro Assistencial Cruz de Malta
Abstract Ethnic origin, genetics, gender and environmental factors have been shown to influence some immunologic indices, so that development of reference values for populations of different backgrounds may be necessary. We have determined the distribution of lymphocyte subsets in healthy Brazilian individuals from birth to adulthood. Lymphocyte subsets were determined using four-colour cytometry in a cross-sectional study of 463 human immunodeficiency virus-unexposed children and adults from birth through 49 years of age. Lymphocyte subsets varied according to age, as previously observed in other studies. However, total CD4+ T cell numbers were lower than what was described in the Pediatric AIDS Clinical Trials Group P1009 (PACTG P1009), which assessed an American population of predominantly African and Hispanic backgrounds until the 12-18 year age range, when values were comparable. Naïve percentages and absolute values of CD8+ T cells, as assessed by CD45RA expression, were also lower than the PACTG P1009 data for all analysed age ranges. CD38 expression on both CD4+ and CD8+ T cells was lower than the PACTG P1009 values, with a widening gap between the two studies at older age ranges. Different patterns of cell differentiation seem to occur in different settings and may have characteristic expression within each population.
Keywords lymphocyte subsets
flow cytometry
immunodiagnostics
clinical profile
HIV
Language English
Date 2014-12-01
Published in Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 109, n. 8, p. 989-998, 2014.
ISSN 0074-0276 (Sherpa/Romeo)
Publisher Instituto Oswaldo Cruz, Ministério da Saúde
Extent 989-998
Origin http://dx.doi.org/10.1590/0074-0276140182
Access rights Open access Open Access
Type Article
SciELO ID S0074-02762014000800989 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8719

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