Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus

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dc.contributor.author Peracchi, Octávio Augusto Bedin [UNIFESP]
dc.contributor.author Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
dc.contributor.author Munekata, Regina Viviane [UNIFESP]
dc.contributor.author Len, Claudio Arnaldo [UNIFESP]
dc.contributor.author Sarni, Roseli Oselka Saccardo [UNIFESP]
dc.contributor.author Lazaretti-Castro, Marise [UNIFESP]
dc.contributor.author Hilário, Maria Odete Esteves [UNIFESP]
dc.date.accessioned 2015-06-14T13:47:14Z
dc.date.available 2015-06-14T13:47:14Z
dc.date.issued 2014-08-01
dc.identifier http://dx.doi.org/10.1590/1414-431X20143948
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 47, n. 8, p. 721-726, 2014.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/8526
dc.description.abstract We evaluated the concentrations of 25-hydroxyvitamin D [25(OH)D] in children and adolescents with juvenile systemic lupus erythematosus (JSLE) and associated them with disease duration and activity, use of medication (chloroquine and glucocorticoids), vitamin D intake, calcium and alkaline phosphatase levels, and bone mineral density. Thirty patients with JSLE were evaluated and compared to 30 healthy individuals, who were age and gender matched. Assessment was performed of clinical status, disease activity, anthropometry, laboratory markers, and bone mineral density. The 30 patients included 25 (83.3%) females and 16 (53.3%) Caucasians, with a mean age of 13.7 years. The mean age at diagnosis was 10.5 years and mean disease duration was 3.4 years. Mean levels of calcium, albumin, and alkaline phosphatase were significantly lower in patients with JSLE compared with controls (P<0.001, P=0.006, and P<0.001, respectively). Twenty-nine patients (97%) and 23 controls (77%) had 25(OH)D concentrations lower than 32 ng/mL, with significant differences between them (P<0.001). Fifteen patients (50%) had vitamin D levels <20 ng/mL and 14 had vitamin D levels between 20 and 32 ng/mL. However, these values were not associated with greater disease activity, higher levels of parathormone, medication intake, or bone mineral density. Vitamin D concentrations were similar with regard to ethnic group, body mass index, height for age, and pubertal stage. Significantly more frequently than in controls, we observed insufficient serum concentrations of 25(OH)D in patients with JSLE; however, we did not observe any association with disease activity, higher levels of parathormone, lower levels of alkaline phosphatase, use of medications, or bone mineral density alterations. en
dc.format.extent 721-726
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Juvenile systemic lupus erythematosus en
dc.subject Vitamin D en
dc.subject Calcium en
dc.subject Bone metabolism en
dc.subject Parathormone en
dc.title Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Pediatria
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Pediatria Unidade de Reumatologia Pediátrica
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina Divisão de Endocrinologia
dc.description.affiliationUnifesp UNIFESP, Depto. de Pediatria
dc.description.affiliationUnifesp UNIFESP, Depto. de Pediatria Unidade de Reumatologia Pediátrica
dc.description.affiliationUnifesp UNIFESP, Depto. de Medicina Divisão de Endocrinologia
dc.identifier.file S0100-879X2014000800721.pdf
dc.identifier.scielo S0100-879X2014000800721
dc.identifier.doi 10.1590/1414-431X20143948
dc.description.source SciELO



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