Aspirin plus calcium supplementation to prevent superimposed preeclampsia: a randomized trial

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dc.contributor.author Souza, E.v.
dc.contributor.author Torloni, Maria Regina [UNIFESP]
dc.contributor.author Atallah, Álvaro Nagib [UNIFESP]
dc.contributor.author Dos Santos, G.m.s.
dc.contributor.author Kulay Jr, L.
dc.contributor.author Sass, Nelson [UNIFESP]
dc.date.accessioned 2015-06-14T13:47:06Z
dc.date.available 2015-06-14T13:47:06Z
dc.date.issued 2014-05-02
dc.identifier http://dx.doi.org/10.1590/1414-431X20143629
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 47, n. 5, p. 419-425, 2014.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/8380
dc.description.abstract Preeclampsia is an important cause of maternal and perinatal morbidity and mortality. Previous studies have tested calcium supplementation and aspirin separately to reduce the incidence of preeclampsia but not the effects of combined supplementation. The objective of this study was to investigate the effectiveness of aspirin combined with calcium supplementation to prevent preeclampsia in women with chronic hypertension. A double-blind, placebo-controlled randomized clinical trial was carried out at the antenatal clinic of a large university hospital in São Paulo, SP, Brazil. A total of 49 women with chronic hypertension and abnormal uterine artery Doppler at 20-27 weeks gestation were randomly assigned to receive placebo (N = 26) or 100 mg aspirin plus 2 g calcium (N = 23) daily until delivery. The main outcome of this pilot study was development of superimposed preeclampsia. Secondary outcomes were fetal growth restriction and preterm birth. The rate of superimposed preeclampsia was 28.6% lower among women receiving aspirin plus calcium than in the placebo group (52.2 vs 73.1%, respectively, P=0.112). The rate of fetal growth restriction was reduced by 80.8% in the supplemented group (25 vs 4.8% in the placebo vs supplemented groups, respectively; P=0.073). The rate of preterm birth was 33.3% in both groups. The combined supplementation of aspirin and calcium starting at 20-27 weeks of gestation produced a nonsignificant decrease in the incidence of superimposed preeclampsia and fetal growth restriction in hypertensive women with abnormal uterine artery Doppler. en
dc.format.extent 419-425
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Preeclampsia en
dc.subject Hypertension en
dc.subject Ultrasonography en
dc.subject Doppler en
dc.subject Calcium carbonate en
dc.subject Aspirin en
dc.title Aspirin plus calcium supplementation to prevent superimposed preeclampsia: a randomized trial en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Obstetrícia
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Estatística Aplicada
dc.description.affiliationUnifesp UNIFESP, Depto. de Obstetrícia
dc.description.affiliationUnifesp UNIFESP, Depto. de Medicina
dc.description.affiliationUnifesp UNIFESP, Depto. de Estatística Aplicada
dc.identifier.file S0100-879X2014000500419.pdf
dc.identifier.scielo S0100-879X2014000500419
dc.identifier.doi 10.1590/1414-431X20143629
dc.description.source SciELO



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