Aspirin plus calcium supplementation to prevent superimposed preeclampsia: a randomized trial

Aspirin plus calcium supplementation to prevent superimposed preeclampsia: a randomized trial

Author Souza, E.v. Google Scholar
Torloni, Maria Regina Autor UNIFESP Google Scholar
Atallah, Álvaro Nagib Autor UNIFESP Google Scholar
Dos Santos, G.m.s. Google Scholar
Kulay Jr, L. Google Scholar
Sass, Nelson Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Preeclampsia is an important cause of maternal and perinatal morbidity and mortality. Previous studies have tested calcium supplementation and aspirin separately to reduce the incidence of preeclampsia but not the effects of combined supplementation. The objective of this study was to investigate the effectiveness of aspirin combined with calcium supplementation to prevent preeclampsia in women with chronic hypertension. A double-blind, placebo-controlled randomized clinical trial was carried out at the antenatal clinic of a large university hospital in São Paulo, SP, Brazil. A total of 49 women with chronic hypertension and abnormal uterine artery Doppler at 20-27 weeks gestation were randomly assigned to receive placebo (N = 26) or 100 mg aspirin plus 2 g calcium (N = 23) daily until delivery. The main outcome of this pilot study was development of superimposed preeclampsia. Secondary outcomes were fetal growth restriction and preterm birth. The rate of superimposed preeclampsia was 28.6% lower among women receiving aspirin plus calcium than in the placebo group (52.2 vs 73.1%, respectively, P=0.112). The rate of fetal growth restriction was reduced by 80.8% in the supplemented group (25 vs 4.8% in the placebo vs supplemented groups, respectively; P=0.073). The rate of preterm birth was 33.3% in both groups. The combined supplementation of aspirin and calcium starting at 20-27 weeks of gestation produced a nonsignificant decrease in the incidence of superimposed preeclampsia and fetal growth restriction in hypertensive women with abnormal uterine artery Doppler.
Keywords Preeclampsia
Hypertension
Ultrasonography
Doppler
Calcium carbonate
Aspirin
Language English
Date 2014-05-02
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 47, n. 5, p. 419-425, 2014.
ISSN 0100-879X (Sherpa/Romeo)
Publisher Associação Brasileira de Divulgação Científica
Extent 419-425
Origin http://dx.doi.org/10.1590/1414-431X20143629
Access rights Open access Open Access
Type Article
SciELO ID S0100-879X2014000500419 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8380

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