Randomized trial - oxybutynin for treatment of persistent plantar hyperhidrosis in women after sympathectomy

Randomized trial - oxybutynin for treatment of persistent plantar hyperhidrosis in women after sympathectomy

Author Costa Junior, Altair da Silva Autor UNIFESP Google Scholar
Leao, Luiz Eduardo Villaca Autor UNIFESP Google Scholar
Succi, José Ernesto Autor UNIFESP Google Scholar
Perfeito, João Aléssio Juliano Autor UNIFESP Google Scholar
Castelo Filho, Adauto Autor UNIFESP Google Scholar
Rymkiewicz, Erika Google Scholar
Marchetti-Filho, Marco Aurelio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE: Hyperhidrosis is a common disease, and thoracoscopic sympathectomy improves its symptoms in up to 95% of cases. Unfortunately, after surgery, plantar hyperhidrosis may remain in 50% of patients, and compensatory sweating may be observed in 70%. This clinical scenario remains a challenge. Our objective was to evaluate the effectiveness of oxybutynin in the treatment of persistent plantar hyperhidrosis and compensatory sweating and its effects on quality of life in women after thoracoscopic sympathectomy. METHOD: We conducted a prospective, randomized study to compare the effects of oxybutynin at 10 mg daily and placebo in women with persistent plantar hyperhidrosis. The assessment was performed using a quality-of-life questionnaire for hyperhidrosis and sweating measurement with a device for quantifying transepidermal water loss. Clinicaltrials.gov: NCT01328015. RESULTS: Sixteen patients were included in each group (placebo and oxybutynin). There were no significant differences between the groups prior to treatment. After oxybutynin treatment, there was a decrease in symptoms and clinical improvement based on the quality-of-life questionnaire (before treatment, 40.4 vs. after treatment, 17.5; p = 0.001). The placebo group showed modest improvement (p = 0.09). The outcomes of the transepidermal water loss measurements in the placebo group showed no differences (p = 0.95), whereas the oxybutynin group revealed a significant decrease (p = 0.001). The most common side effect was dry mouth (100% in the oxybutynin group vs. 43.8% in the placebo group; p = 0.001). CONCLUSION: Oxybutynin was effective in the treatment of persistent plantar hyperhidrosis, resulting in a better quality of life in women who had undergone thoracoscopic sympathectomy.
Keywords Hyperhidrosis
Thoracic Surgery
Oxybutynin
Language English
Date 2014-02-01
Published in Clinics. Faculdade de Medicina / USP, v. 69, n. 2, p. 101-105, 2014.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
1980-5322 (Sherpa/Romeo, impact factor)
Publisher Faculdade de Medicina / USP
Extent 101-105
Origin http://dx.doi.org/10.6061/clinics/2014(02)05
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000331931800005
SciELO ID S1807-59322014000200101 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8219

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