Analysis of the effect of renal excretory system cooling during thermal radiofrequency ablation in an animal model

Analysis of the effect of renal excretory system cooling during thermal radiofrequency ablation in an animal model

Author Meireles, Andre Google Scholar
Taha Neto, Khaled Ahmed Google Scholar
Castilho, Lisias Nogueira Google Scholar
D'Ippolito, Giuseppe Autor UNIFESP Google Scholar
Reis, Leonardo Oliveira Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Radium Institute
Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: Analysis of renal excretory system integrity and efficacy of radiofrequency ablation with and without irrigation with saline at 2 o C (SF2). Materials and Methods: The median third of sixteen kidneys were submitted to radiofrequency (exposition of 1 cm) controlled by intra-surgical ultrasound, with eight minutes cycles and median temperature of 90 o C in eight female pigs. One excretory renal system was cooled with SF2, at a 30ml/min rate, and the other kidney was not. After 14 days of post-operatory, the biggest diameters of the lesions and the radiological aspects of the excretory system were compared by bilateral ascending pyelogram and the animals were sacrificed in order to perform histological analysis. Results: There were no significant differences between the diameters of the kidney lesions whether or not exposed to cooling of the excretory system. Median diameter of the cooled kidneys and not cooled kidneys were respectively (in mm): anteroposterior: 11.46 vs. 12.5 (p = 0.23); longitudinal: 17.94 vs. 18.84 (p = 0.62); depth: 11.38 vs. 12.25 (p = 0.47). There was no lesion of the excretory system or signs of leakage of contrast media or hydronephrosis at ascending pyelogram. Conclusion: Cooling of excretory system during radiofrequency ablation does not significantly alter generated coagulation necrosis or affect the integrity of the excretory system in the studied model.
Keywords Carcinoma, Renal Cell
Ablation Techniques
Therapeutics
Hyperthermia, Induced
Catheters
Language English
Date 2014-01-01
Published in International braz j urol. Sociedade Brasileira de Urologia, v. 40, n. 1, p. 93-99, 2014.
ISSN 1677-5538 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira de Urologia
Extent 93-99
Origin http://dx.doi.org/10.1590/S1677-5538.IBJU.2014.01.14
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000335430800016
SciELO ID S1677-55382014000100093 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8169

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