Histological modification in TRAM flap in rats treated with pentoxifylline

Histological modification in TRAM flap in rats treated with pentoxifylline

Author Lucca, Audrien Furlan de Google Scholar
Brasolin, Adriano Guimarães Google Scholar
Feitosa, Roney Gonçalves Fechine Google Scholar
Enokihara, Milvia Maria Simões e Silva Google Scholar
Gomes, Heitor Francisco de Carvalho Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract PURPOSE: To investigate the blood vessels' concentration in TRAM flap's rat model, in the presence of pentoxifylline.METHODS:32 male, Wistar-EPM rats were divided into two groups. Control group (C): 0.5 ml of saline, intraperitoneally, once a day, for seven days before flap elevation; PTX group (P): pentoxifylline (20mg/kg/day), intraperitoneally, for seven days before flap elevation. After that, they were submitted to a caudal unipedicle TRAM flap. On the fifth postoperative day, percentages of flap necrosis were determined via the paper template method and Tram flap's zone IV skin biopsies were taken for histological analysis.RESULTS:the mean percentage of flap necrosis in group C was 58.7 % and in group P, 31.1 (Wilcoxon test; p = 0.003). Mean capillary vessels number in zone IV's skin in C group was 33.4 and in P group was 71.9 (p=0.008).CONCLUSIONS: Pentoxifylline was effective reducing the necrosis in the caudal unipedicle TRAM flap in the rat as well as increasing the number of capillaries in an ischemic zone (zone IV).
Keywords Pentoxifylline
Surgical flaps
Graft survival
Rats
Language English
Date 2014-01-01
Published in Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, p. 34-37, 2014.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extent 34-37
Origin http://dx.doi.org/10.1590/S0102-86502014001400007
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000342065300008
SciELO ID S0102-86502014001400008 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8163

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