Neovascularization after surgical exposure of rat external jugular vein endothelium

Neovascularization after surgical exposure of rat external jugular vein endothelium

Author Nascimento, José Francimário Bezerra Do Autor UNIFESP Google Scholar
Pitta, Guilherme Brandão Benjamin Google Scholar
Miranda Junior, Fausto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
University of Health Sciences of Alagoas Department of Surgery
Abstract PURPOSE: To investigate the neovascularization after exposure of the external jugular venous endothelium in an experimental model. METHODS: The sample was composed of 60 male rats of Wistar OUT B breed provided by animal colony of the Medicine College of Juazeiro do Norte, weighing 250 to 350g, aged 90-120 days. Randomized study in OUT B Wistar rats, open, with 60 days duration. The animals were distributed into three groups of 20 specimens and were subjected to the following: Group 1: neck incision with dissection, ligation and section of the external jugular vein. Group 2: neck incision with dissection and ligation of the external jugular vein. Group 3: cervicotomy without dissection of the external jugular vein without ligation or section. The animals were sacrificed, half of them in 30 days and the other half within 60 days. The material in block harvested from the operated site were sectioned and stained for immunohistochemistry with CD34 marker. RESULTS: Neovascularization occurred with level of significance when compared group 1 to group 3 at 30 days (p=0.0076) and the same occurred at 60 days (p=0.0001) (Newman-Keuls test). CONCLUSION: The group with exposure of the venous endothelium showed a significant increase of neovascularization when compared with other groups.
Keywords Neovascularization
Jugular Veins
Endothelium
Rats
Language English
Date 2013-12-01
Published in Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 12, p. 820-823, 2013.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extent 820-823
Origin http://dx.doi.org/10.1590/S0102-86502013001200003
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000328649900003
SciELO ID S0102-86502013001200003 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8078

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