Current perception threshold and reaction time in the assessment of sensory peripheral nerve fibers through sinusoidal electrical stimulation at different frequencies

Current perception threshold and reaction time in the assessment of sensory peripheral nerve fibers through sinusoidal electrical stimulation at different frequencies

Author Martins, Henrique Resende Google Scholar
Zanetti, Renato Google Scholar
Santos, Clarissa Cardoso Dos Google Scholar
Manzano, Gilberto Mastrocola Autor UNIFESP Google Scholar
Tierra-criollo, Carlos Julio Google Scholar
Institution Universidade Federal de Minas Gerais Programa de Pós-Graduação em Engenharia Elétrica
Universidade de Brasília Faculdade de Ceilândia
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro Centro de Tecnologia Programa de Engenharia Biomédica
Abstract INTRODUCTION: The Perception Sensory Threshold (ST) for sinusoidal current stimuli at 5, 250, and 2,000 Hz is commonly used in the assessment of peripheral nerve fibers (C, Aδ, and Aβ, respectively). However, the neuroselectivity of these frequencies is far from consensus. In addition, Reaction Time (RT) measurements suggest that 2,000 Hz stimuli excite Aβ-fibers, 250 Hz Aβ- or Aδ-fibers, as well as 5 Hz Aβ-, Aδ- or C-fibers. Therefore, we suppose that the sinusoidal current neuroselectivity may be better observed if ST and RT parameters are jointly evaluated. In addition, we have investigated whether there are other sets of frequencies that could be used. METHODS: Thus this work investigates ST and RT for stimuli with frequency ranging from 1 to 3,000 Hz, on 28 healthy subjects aged from 19 to 44 years old (27.1±5.49). ST and RT dissimilarity among different frequencies was evaluated applying bi-dimensional Fisher Quadratic Discriminant. RESULTS: The lowest classification error (3.6%) was obtained for 1, 250, and 3,000 Hz. Error for 5, 250, and 2,000Hz was 16.7%. Stimulation frequency at 1 Hz evoked more sensations related to C-fibers (53% of reports) than to Aβ-fibers (36%). However, this behavior did not repeat itself at 5 Hz (only 21% of perceptions were related to C-fibers against 64% to Aβ-fibers). Sensations related to Aβ-fibers prevailed for the highest frequencies presented to the subjects (2,000 Hz - 82% and 3,000 Hz - 93%). Mean RT values showed a decreasing trend with frequency. CONCLUSION: These results suggest that frequencies 1, 250, and 3,000 Hz are more neuroselective than 5, 250, and 2,000 Hz for the evaluation of peripheral sensitive fibers. Furthermore, they show RT usefulness.
Keywords Sensory threshold
Reaction Time
Current Perception Threshold (CPT)
Nervous fibers evaluation
peripheral neuropathies
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Date 2013-09-01
Published in Revista Brasileira de Engenharia Biomédica. SBEB - Sociedade Brasileira de Engenharia Biomédica, v. 29, n. 3, p. 278-285, 2013.
ISSN 1517-3151 (Sherpa/Romeo)
Publisher SBEB - Sociedade Brasileira de Engenharia Biomédica
Extent 278-285
Origin http://dx.doi.org/10.4322/rbeb.2013.028
Access rights Open access Open Access
Type Article
SciELO ID S1517-31512013000300008 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/7942

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