Abdominal wall healing in incisional hernia using different biomaterials in rabbits

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dc.contributor.author Aramayo, Ana Letícia Gomes [UNIFESP]
dc.contributor.author Lopes Filho, Gaspar de Jesus [UNIFESP]
dc.contributor.author Barbosa, Cirênio de Almeida
dc.contributor.author Amaral, Vânia da Fonseca
dc.contributor.author Costa, Luciano Assis
dc.date.accessioned 2015-06-14T13:45:21Z
dc.date.available 2015-06-14T13:45:21Z
dc.date.issued 2013-04-01
dc.identifier http://dx.doi.org/10.1590/S0102-86502013000400011
dc.identifier.citation Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 4, p. 307-316, 2013.
dc.identifier.issn 0102-8650
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/7681
dc.description.abstract PURPOSE: To investigate abdominal wound healing using specific biomaterials in incisional hernias. METHODS: Incisional hernias were produced in 40 rabbits, after that they were reoperated with or without the use of meshes: PREMILENE® (PPL), ULTRAPRO® (UP), PROCEED® (PCD) or repairing without mesh (TRANSPALB). After 30 days a macroscopic and microscopic study of the part withdrawn from the abdominal wall was performed. RESULTS: Macroscopic: adhesion Area: PPL> UP and PCD (p = 0.031). Vascularization: PPL> UP and PCD (p = 0.001). PPL groups (p = 0.032) and PCD (p <0.001) showed greater meshes shrinkages when compared to UP. Microscopic: neutrophils: PCD> PPL, UP and TRANSPALB (p = 0.010); eosinophils: PPL> UP, and TRANSPALB PCD (p = 0.010); granulation tissue: PPL and PCD> UP and TRANSPALB (p <0.001); macrophages : PPL, UP and PCD> TRANSPALB (p <0.001); lymphocytes: PPL and PCD> UP (p = 0.009) and TRANSPALB (p <0.001); giant cells: PPL, UP and PCD> TRANSPALB (p <0.001); viscera adhered: PPL and UP> PCD and TRANSPALB (p <0.001). CONCLUSION: All types of meshes caused the formation of adhesions. The UP and PCD groups showed lower area and vascularization of the adhesions. The PPL and PCD groups showed higher meshes shrinkage and there was a predominance of acute inflammatory process in the PCD group. en
dc.format.extent 307-316
dc.language.iso eng
dc.publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartof Acta Cirurgica Brasileira
dc.rights Acesso aberto
dc.subject Wound Healing en
dc.subject Abdominal Wall. Hernia, Ventral en
dc.subject Surgical Mesh en
dc.subject Adhesions en
dc.subject Biomaterials en
dc.subject Materials Testing en
dc.subject Animal Experimentation en
dc.subject Rabbits en
dc.title Abdominal wall healing in incisional hernia using different biomaterials in rabbits en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution University of Medical Sciences of Minas Gerais FCMMG Surgery Department
dc.contributor.institution Federal University of Minas Gerais Department of General Pathology
dc.contributor.institution FCMMG
dc.description.affiliation UNIFESP Paulista Medical School Postgraduate Program in Interdisciplinary Surgical Sciences
dc.description.affiliation UNIFESP Paulista Medical School Gastrointestinal Division
dc.description.affiliation University of Medical Sciences of Minas Gerais FCMMG Surgery Department
dc.description.affiliation Federal University of Minas Gerais Department of General Pathology
dc.description.affiliation FCMMG
dc.description.affiliationUnifesp UNIFESP, Paulista Medical School Postgraduate Program in Interdisciplinary Surgical Sciences
dc.description.affiliationUnifesp UNIFESP, Paulista Medical School Gastrointestinal Division
dc.identifier.file S0102-86502013000400011.pdf
dc.identifier.scielo S0102-86502013000400011
dc.identifier.doi 10.1590/S0102-86502013000400011
dc.description.source SciELO
dc.identifier.wos WOS:000317522300011



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