A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury

A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury

Author Ramallo, Bianca Trovello Autor UNIFESP Google Scholar
Lourenço, Elizete Autor UNIFESP Google Scholar
Cruz, Renata Harumi Autor UNIFESP Google Scholar
Almeida, Jacqueline Camargo Autor UNIFESP Google Scholar
Taha, Murched Omar Autor UNIFESP Google Scholar
Silva, Priscilla Yuri Okochi Alves Autor UNIFESP Google Scholar
Oliveira-Júnior, Itamar Souza Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract PURPOSE: To investigate the protective effects of pentoxifylline against lung injury observed after dorsal scald in aged animals. METHODS: Adult (eight months old) and aged (20 months old) rats were subjected to thermal injury or sham procedure. The six hours post-trauma animals received pentoxifylline and after 24 hours were euthanatized and lung tissue samples collectedted. The bronchoalveolar lavage fluid was evaluated for total protein content and tumor necrosis factor-alpha cytokine. Malondialdehyde and myeloperoxidase activety in the lung homogenate were measured and a histological lung examination was undertaken. RESULTS: Burn injury induced oxidative stress in lung homogenate was higher in elderly-burned rats compared to adult-burned rats (p<0.001). Total protein and cytokine in bronchoalveolar lavage increased in the elderly-burned group when compared to the adult-burned group (p<0.001). All parameters decreased in bolth groups treated with pentoxifylline (p<0.05). CONCLUSIONS: The injury was augmented in elderly rats when compared to adult rats. Damage was reduced with the use of pentoxifylline, however further studies are needed to evaluate the dose-response of the drug.
Keywords Burns
Aging
Lung Injury
Cytokines
Pentoxifylline
Rats
Language English
Date 2013-02-01
Published in Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 2, p. 154-159, 2013.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extent 154-159
Origin http://dx.doi.org/10.1590/S0102-86502013000200012
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000314365100012
SciELO ID S0102-86502013000200012 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/7618

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