Body composition and lipodystrophy in prepubertal HIV-infected children

Body composition and lipodystrophy in prepubertal HIV-infected children

Author Palchetti, Cecília Zanin Autor UNIFESP Google Scholar
Patin, Rose Vega Autor UNIFESP Google Scholar
Gouvêa, Aida de Fátima Thomé Barbosa Autor UNIFESP Google Scholar
Szejnfeld, Vera Lucia Autor UNIFESP Google Scholar
Succi, Regina Célia de Menezes Autor UNIFESP Google Scholar
Oliveira, Fernanda Luisa Ceragioli Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. METHODS: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care Center of the Division of Pediatric Infectious Diseases - Universidade Federal de São Paulo (UNIFESP), São Paulo city, Brazil, was carried out from August to December 2008. Age, clinical and immunological status, prophylaxis, transmission and highly active antiretroviral therapy were recorded. Body mass index z-score and height-for-age z-score were calculated to characterize the nutritional status. Circumferences were measured with flexible tape and skinfolds were assessed by an adipometry. Fat mass and lean mass were determined by dual-energy X-ray absorptiometry. Presence of clinical signs of lipodystrophy was assessed by a trained clinician. Data were analyzed using SPSS 12.0 software. RESULTS: The mean age and standard deviation were 9.8 (1.2) years, 50% were girls and 82.5% children from B and C categories. Clinical lipodystrophy and dislypidemia were present in 27.5% and 70%, respectively. The trunk to arm ratio and the limb to trunk ratio had positive association with lipodystrophy. Patients with lipodystrophy had short stature, higher triglycerides values and lower HDL-cholesterol. CONCLUSION: The ratios obtained by skinfolds and dual-energy X-ray absorptiometry measurements can be considered as indicators of preclinical lipodystrophy. The cutoff points have not been determined yet; however, continuous assessment may be useful to identify early body composition changes.
Keywords HIV
Child
Lipodystrophy
Body composition
Anthropometry
Language English
Date 2013-02-01
Published in Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 17, n. 1, p. 01-06, 2013.
ISSN 1413-8670 (Sherpa/Romeo, impact factor)
Publisher Brazilian Society of Infectious Diseases
Extent 01-06
Origin http://dx.doi.org/10.1016/j.bjid.2012.12.001
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000315068200001
SciELO ID S1413-86702013000100001 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/7617

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