Dynamics of chest wall volume regulation during constant work rate exercise in patients with chronic obstructive pulmonary disease

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dc.contributor.author Takara, Luciana Shimizu [UNIFESP]
dc.contributor.author Cunha, Thulio Marquez [UNIFESP]
dc.contributor.author Barbosa, Priscila Boaventura [UNIFESP]
dc.contributor.author Rodrigues, Miguel Koite [UNIFESP]
dc.contributor.author Oliveira, Mayron Faria [UNIFESP]
dc.contributor.author Nery, Luiz Eduardo [UNIFESP]
dc.contributor.author Neder, Jose Alberto [UNIFESP]
dc.date.accessioned 2015-06-14T13:45:07Z
dc.date.available 2015-06-14T13:45:07Z
dc.date.issued 2012-12-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2012001200024
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 45, n. 12, p. 1276-1283, 2012.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/7481
dc.description.abstract This study evaluated the dynamic behavior of total and compartmental chest wall volumes [(V CW) = rib cage (V RC) + abdomen (V AB)] as measured breath-by-breath by optoelectronic plethysmography during constant-load exercise in patients with stable chronic obstructive pulmonary disease. Thirty males (GOLD stages II-III) underwent a cardiopulmonary exercise test to the limit of tolerance (Tlim) at 75% of peak work rate on an electronically braked cycle ergometer. Exercise-induced dynamic hyperinflation was considered to be present when end-expiratory (EE) V CW increased in relation to resting values. There was a noticeable heterogeneity in the patterns of V CW regulation as EEV CW increased non-linearly in 17/30 hyperinflators and decreased in 13/30 non-hyperinflators (P < 0.05). EEV AB decreased slightly in 8 of the hyperinflators, thereby reducing and slowing the rate of increase in end-inspiratory (EI) V CW (P < 0.05). In contrast, decreases in EEV CW in the non-hyperinflators were due to the combination of stable EEV RC with marked reductions in EEV AB. These patients showed lower EIV CW and end-exercise dyspnea scores but longer Tlim than their counterparts (P < 0.05). Dyspnea increased and Tlim decreased non-linearly with a faster rate of increase in EIV CW regardless of the presence or absence of dynamic hyperinflation (P < 0.001). However, no significant between-group differences were observed in metabolic, pulmonary gas exchange and cardiovascular responses to exercise. Chest wall volumes are continuously regulated during exercise in order to postpone (or even avoid) their migration to higher operating volumes in patients with COPD, a dynamic process that is strongly dependent on the behavior of the abdominal compartment. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 1276-1283
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Exertion en
dc.subject Lung mechanics en
dc.subject COPD en
dc.subject Dyspnea en
dc.subject Exercise test en
dc.title Dynamics of chest wall volume regulation during constant work rate exercise in patients with chronic obstructive pulmonary disease en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Queen&#8217;s University Department of Medicine Division of Respiratory and Critical Care Medicine
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina Disciplina de Pneumologia
dc.description.affiliation Queen&#8217;s University Department of Medicine Division of Respiratory and Critical Care Medicine
dc.description.affiliationUnifesp UNIFESP, Depto. de Medicina Disciplina de Pneumologia
dc.identifier.file S0100-879X2012001200024.pdf
dc.identifier.scielo S0100-879X2012001200024
dc.identifier.doi 10.1590/S0100-879X2012001200024
dc.description.source SciELO
dc.identifier.wos WOS:000312461700024



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