Analysis of p53 expression and proliferative assessment using PCNA in localized prostate carcinoma

Analysis of p53 expression and proliferative assessment using PCNA in localized prostate carcinoma

Author Leite, Kátia Ramos Moreira Autor UNIFESP Google Scholar
Srougi, Miguel Autor UNIFESP Google Scholar
Nesrallah, Luciano João Autor UNIFESP Google Scholar
Camara-Lopes, Luiz H Autor UNIFESP Google Scholar
Institution Hospital Sírio Libanês
Universidade Federal de São Paulo (UNIFESP)
Abstract The surgical specimens from 51 men submitted to radical prostatectomy for localized prostate cancer were examined by immunohistochemistry using proliferation cell nuclear antigen (PCNA) monoclonal antibody to evaluate the proliferative index (PI). The relationship between PI, biological variables and p53 protein expression was evaluated by immunohistochemistry. PI was low in invasive localized prostate carcinoma (mean, 12.4%) and the incidence of PCNA-positive cells was significantly higher in tumors with p53 expression (P = 0.0226). There was no statistical difference in PCNA values when biological parameters such as Gleason score, tumor volume, extraprostatic involvement, seminal vesicle infiltration or lymph node metastasis were considered. We conclude that proliferative activity is usually low in prostate carcinoma but is correlated with p53 immune staining, indicating that p53 is important in cell cycle control in this neoplasm.
Keywords prostate carcinoma
p53
proliferating cell nuclear antigen
PCNA
Language English
Date 1999-03-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 3, p. 283-288, 1999.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 283-288
Origin http://dx.doi.org/10.1590/S0100-879X1999000300006
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000079438000006
SciELO ID S0100-879X1999000300006 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/744

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