Wound-healing and benzodiazepines: does sleep play a role in this relationship?

Wound-healing and benzodiazepines: does sleep play a role in this relationship?

Author Egydio, Flavia Autor UNIFESP Google Scholar
Pires, Gabriel Natan Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Patients who have suffered burns frequently experience psychological consequences, among which anxiety disorders are prominent. Benzodiazepines are commonly administered to treat these symptoms. The effects of benzodiazepines on healing may not be direct but rather are modulated by alterations of the sleep architecture. This hypothesis is supported by studies that demonstrate the effects of benzodiazepines on the immune system and the inflammatory profile under both normal sleep conditions and during sleep deprivation, particularly rapid eye movement sleep deprivation.
Keywords Benzodiazepines
Sleep Deprivation
Wound Healing
Burns
Immune System
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP (CEPID)
Grant number 2011/14462-0 e 2010/14768-0
98/14303-3
Date 2012-07-01
Published in Clinics. Faculdade de Medicina / USP, v. 67, n. 7, p. 827-830, 2012.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
Publisher Faculdade de Medicina / USP
Extent 827-830
Origin http://dx.doi.org/10.6061/clinics/2012(07)20
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000307723100020
SciELO ID S1807-59322012000700020 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/7193

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