Tissue expression of CD10 protein in colorectal carcinoma: correlation with the anatomopathological features of the tumor and with lymph node and liver metastases

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dc.contributor.author Oliveira, Levindo Alves de [UNIFESP]
dc.contributor.author Artigiani Neto, Ricardo [UNIFESP]
dc.contributor.author Joppert Netto, George [UNIFESP]
dc.contributor.author Sznirer, Monica [UNIFESP]
dc.contributor.author Fernandes, Luis Cesar [UNIFESP]
dc.contributor.author Lima, Flávio de Oliveira [UNIFESP]
dc.contributor.author Waisberg, Jaques [UNIFESP]
dc.date.accessioned 2015-06-14T13:43:39Z
dc.date.available 2015-06-14T13:43:39Z
dc.date.issued 2012-03-01
dc.identifier http://dx.doi.org/10.1590/S2237-93632012000100005
dc.identifier.citation Journal of Coloproctology (Rio de Janeiro). Sociedade Brasileira de Coloproctologia, v. 32, n. 1, p. 34-39, 2012.
dc.identifier.issn 2237-9363
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/7005
dc.description.abstract BACKGROUND: The reduced expression of CD10 may be related to unfavorable prognosis of patients with colorectal carcinoma. The authors analyzed the tissue immunostaining of CD10 protein in colorectal carcinoma and its relationship to clinicopathologic features. METHOD: In 130 patients submitted to colorectal carcinoma surgery, a tissue microarray block was obtained from the tumor and adjacent non-neoplastic mucosa and submitted to immunohistochemistry with monoclonal antibody CD10. The immunostaining was evaluated by semi-quantitative method, with stained cell count in percentage. The results were related to the location, anatomopathological features, presence of lymph node and hepatic metastases and TNM staging of the colorectal neoplasm. The statistical analysis was performed with the Mann-Whitney, Kruskal-Wallis and Fisher exact tests. RESULTS: The expression of CD10 marker was higher in colorectal tumor tissue than in adjacent non-neoplastic mucosa (p<0.0001) and was higher than in exophytic lesions (p=0.04). The expression of CD10 protein was not associated with other clinical and pathological aspects of colorectal neoplasm. CONCLUSIONS: The expression of CD10 protein was more intense in tumor tissue of colorectal carcinoma than in adjacent non-neoplastic mucosa and was related to the exophytic appearance of the tumor. en
dc.description.abstract INTRODUÇÃO: A expressão reduzida de CD10 pode estar relacionada com prognóstico desfavorável de doentes com carcinoma colorretal. Analisou-se a imunoexpressão tecidual da proteína CD10 no carcinoma colorretal e sua relação com os aspectos clinicopatológicos. MÉTODO: Em 130 doentes operados por carcinoma colorretal, um bloco de tissue microarray foi obtido do tecido neoplásico e da mucosa não neoplásica adjacente e submetido ao estudo imuno-histoquímico com anticorpo monoclonal CD10. Avaliou-se a imunoexpressão por método semiquantitativo, com contagem do percentual de células coradas. Os resultados foram relacionados com a localização, aspectos anatomopatológicos, presença de metástases linfonodais e hepáticas e estadiamento TNM da neoplasia. O estudo estatístico foi realizado com os testes de Mann-Whitney, Kruskal-Wallis e exato de Fisher. RESULTADOS: A expressão do marcador CD10 foi maior no tecido do carcinoma colorretal do que na mucosa não neoplásica adjacente (p<0,0001) e foi maior nas lesões exofíticas (p=0,04). A expressão da proteína CD10 não apresentou relação com os demais aspetos clínicos e patológicos da neoplasia colorretal. CONCLUSÕES: A expressão da proteína CD10 foi mais intensa no tecido neoplásico do carcinoma colorretal do que na mucosa não neoplásica adjacente e relacionou-se com o aspecto exofítico do tumor. pt
dc.format.extent 34-39
dc.language.iso eng
dc.publisher Sociedade Brasileira de Coloproctologia
dc.relation.ispartof Journal of Coloproctology (Rio de Janeiro)
dc.rights Acesso aberto
dc.subject Neoplasm antigens en
dc.subject Colorectal neoplasms en
dc.subject Prognosis en
dc.subject Neoplasm metastasis en
dc.subject CD10 antigens en
dc.subject Antígenos de neoplasia pt
dc.subject Neoplasias colorretais pt
dc.subject Prognóstico pt
dc.subject Metástase neoplásica pt
dc.subject Antígenos CD10 pt
dc.title Tissue expression of CD10 protein in colorectal carcinoma: correlation with the anatomopathological features of the tumor and with lymph node and liver metastases en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Department of Surgery
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Department of Pathology
dc.description.affiliationUnifesp UNIFESP, EPM, Department of Surgery
dc.description.affiliationUnifesp UNIFESP, EPM, Department of Pathology
dc.identifier.file S2237-93632012000100005.pdf
dc.identifier.scielo S2237-93632012000100005
dc.identifier.doi 10.1590/S2237-93632012000100005
dc.description.source SciELO



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