Primary systemic amyloidosis associated with multiple myeloma

Primary systemic amyloidosis associated with multiple myeloma

Alternative title Amiloidose sistêmica primária associada ao mieloma múltiplo
Author Oliveira, Ederson Valei Lopes De Google Scholar
Pozetti, Ana Carolina Garcia Google Scholar
Pozetti, Eurides Maria De Oliveira Google Scholar
Antonio, João Roberto Google Scholar
Michalany, Nilceo Schwery Autor UNIFESP Google Scholar
Institution Faculdade de Medicina de São José do Rio Preto
Universidade Federal de São Paulo (UNIFESP)
Abstract This case report is about a 48-year-old female patient with systemic amyloidosis and multiple myeloma simultaneously. Amyloid cutaneous infiltrative lesions like papules, nodules, or plaques with a serous-hemorrhagic aspect were found in the eyelids, neck and retroauricular region, among others. She had presented intermittent papular lesions on the upper eyelids one year before, which worsened following local trauma. A local skin biopsy showed amorphous and eosinophilic substance in the dermis. Congo red staining confirmed the amyloid deposits. Abnormal exams: proteinuria (570mg/24h), Bence-Jones proteinuria and clonal plasma cells (70%) found in myelogram. Following the diagnosis of multiple myeloma based on amyloid skin lesions, the patient was referred to the Hematology service and died 5 months after the diagnosis.

Relatamos um caso de uma paciente de 48 anos com amiloidose sistêmica associada a mieloma múltiplo. Lesões infiltrativas cutâneas como pápulas, nódulos ou placas com aspecto sero-hemorrágico podem ser localizados nas pálpebras, pescoço, região retroauricular dentre outras. No presente caso, as pálpebras foram acometidas por pápulas, há 1 ano, de caráter intermitente e piora após trauma local. Biópsia local evidenciou material amorfo e eosinofílico na derme. A coloração vermelho do Congo confirmou presença de substância amiloide. Exames anormais: proteinúria de 570mg/24 horas, proteinúria de Bence-Jones positiva e mielograma com 70% de plasmócitos atípicos. Assim, realizou-se o diagnóstico de mieloma múltiplo a partir de manifestações cutâneas de amiloidose. Paciente encaminhada ao serviço de hematologia e foi a óbito em 5 meses.
Keywords Amyloidosis
Eyelids
Multiple myeloma
Skin
Amiloidose
Mieloma múltiplo
Pálpebras
Pele
Language English
Date 2012-02-01
Published in Anais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 87, n. 1, p. 119-122, 2012.
ISSN 0365-0596 (Sherpa/Romeo)
Publisher Sociedade Brasileira de Dermatologia
Extent 119-122
Origin http://dx.doi.org/10.1590/S0365-05962012000100015
Access rights Open access Open Access
Type Article
SciELO ID S0365-05962012000100015 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6960

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