Histochemical study of the skeletal muscle in children with chronic renal failure in dialysis treatment

Histochemical study of the skeletal muscle in children with chronic renal failure in dialysis treatment

Alternative title Estudo histoquímico do músculo esquelético em crianças com insuficiência renal crônica em tratamento dialítico
Author Prado, Lucila Bizari Fernandes do Autor UNIFESP Google Scholar
Prado, Gilmar Fernandes do Autor UNIFESP Google Scholar
Oliveira, Acary Souza Bulle Autor UNIFESP Google Scholar
Schmidt, Beny Autor UNIFESP Google Scholar
Carvalhaes, João Tomás de Abreu Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Among the modifications occurring in the uremic organism, in addition to the consequences of dialysis, myophathy and peripheral neuropathy are very significant. Children are particularly affected, as their growth and development are jeopardized. Histochemistry of muscular biopsy was used to study eighteen children with end-stage renal failure under dialysis during a ten-month period. According to our results, the skeletal muscular tissue presented the following types of alterations: atrophy, type grouping, lipidosis, glycogen depletion and mitochondrial proliferation.

Dentre as modificações que o organismo urêmico sofre, acrescido das consequências do tratamento dialítico, miopatia e neuropatia periférica são de real importância. A criança é particularmente afetada, pois seu crescimento e desenvolvimento estão comprometidos. Foram estudadas dezoito crianças com insuficiência renal crônica terminal em programa de diálise, num período de dez meses, através da histoquímica da biópsia muscular. Segundo nossos resultados, o tecido muscular esquelético apresentou alterações tipo atrofia, type grouping, lipidose, depleção de glicogênio e proliferação mitocondrial.
Keywords chronic renal failure
dialysis
muscular biopsy
uremia
insuficiência renal crônica
diálise
biópsia muscular
uremia
Language English
Date 1998-09-01
Published in Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 56, n. 3A, p. 381-387, 1998.
ISSN 0004-282X (Sherpa/Romeo, impact factor)
Publisher Academia Brasileira de Neurologia - ABNEURO
Extent 381-387
Origin http://dx.doi.org/10.1590/S0004-282X1998000300006
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000075266000006
SciELO ID S0004-282X1998000300006 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/673

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