Results from transcranial Doppler examination on children and adolescents with sickle cell disease and correlation between the time-averaged maximum mean velocity and hematological characteristics: a cross-sectional analytical study

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dc.contributor.author Hokazono, Mary [UNIFESP]
dc.contributor.author Silva, Gisele Sampaio [UNIFESP]
dc.contributor.author Silva, Edina Mariko Koga da [UNIFESP]
dc.contributor.author Braga, Josefina Aparecida Pellegrini [UNIFESP]
dc.date.accessioned 2015-06-14T13:43:03Z
dc.date.available 2015-06-14T13:43:03Z
dc.date.issued 2011-05-01
dc.identifier http://dx.doi.org/10.1590/S1516-31802011000300003
dc.identifier.citation HOKAZONO, Mary et al . Results from transcranial Doppler examination on children and adolescents with sickle cell disease and correlation between the time-averaged maximum mean velocity and hematological characteristics: a cross-sectional analytical study. Sao Paulo Med. J., São Paulo , v. 129, n. 3, p. 134-138, maio 2011
dc.identifier.issn 1516-3180
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/6439
dc.description.abstract CONTEXT AND OBJECTIVE: Transcranial Doppler (TCD) detects stroke risk among children with sickle cell anemia (SCA). Our aim was to evaluate TCD findings in patients with different sickle cell disease (SCD) genotypes and correlate the time-averaged maximum mean (TAMM) velocity with hematological characteristics. DESIGN AND SETTING: Cross-sectional analytical study in the Pediatric Hematology sector, Universidade Federal de São Paulo (UNIFESP). METHODS: 85 SCD patients of both sexes, aged 2-18 years, were evaluated, divided into: group I (62 patients with SCA/Sß0 thalassemia); and group II (23 patients with SC hemoglobinopathy/Sß+ thalassemia). TCD was performed and reviewed by a single investigator using Doppler ultrasonography with a 2 MHz transducer, in accordance with the Stroke Prevention Trial in Sickle Cell Anemia (STOP) protocol. The hematological parameters evaluated were: hematocrit, hemoglobin, reticulocytes, leukocytes, platelets and fetal hemoglobin. Univariate analysis was performed and Pearson's coefficient was calculated for hematological parameters and TAMM velocities (P < 0.05). RESULTS: TAMM velocities were 137 ± 28 and 103 ± 19 cm/s in groups I and II, respectively, and correlated negatively with hematocrit and hemoglobin in group I. There was one abnormal result (1.6%) and five conditional results (8.1%) in group I. All results were normal in group II. Middle cerebral arteries were the only vessels affected. CONCLUSION: There was a low prevalence of abnormal Doppler results in patients with sickle-cell disease. Time-average maximum mean velocity was significantly different between the genotypes and correlated with hematological characteristics. en
dc.description.abstract CONTEXTO E OBJETIVO: Doppler transcraniano (DTC) detecta risco de acidente vascular cerebral (AVC) em crianças com anemia falciforme (AF). O objetivo foi avaliar os resultados ao DTC nos diferentes genótipos da doença falciforme (DF) e correlacionar a velocidade média-máxima (VMMáx) às características hematológicas. TIPO DE ESTUDO E LOCAL: Estudo transversal analítico realizado no setor de Hematopediatria da Universidade Federal de São Paulo (UNIFESP). MÉTODOS: 85 pacientes com DF, 2-18 anos, ambos os sexos, foram avaliados e divididos em: grupo I (62 com AF ou Sß0 talassemia); e grupo II (23 com hemoglobinopatia SC ou Sß+ talassemia). DTC foi realizado e revisado por um único investigador usando um aparelho de ultrassonografia Doppler com transdutor de 2MHz, conforme critérios do protocolo STOP (Stroke Prevention Trial in Sickle Cell Anemia). As variáveis hematológicas avaliadas foram: hematócrito, hemoglobina, reticulócitos, leucócitos, plaquetas, hemoglobina fetal. Análise univariada e coeficiente de Pearson calculados para parâmetros hematológicos e VMMáx, P < 0,05. RESULTADOS: As média das VMMáx foram de 137 ± 28 cm/s e 103 ± 19 cm/s nos grupos I e II, respectivamente. Houve correlação negativa da VMMáx com hematócrito e hemoglobina no grupo I. Houve um (1,6%) resultado anormal e 5 (8,1%) condicionais no grupo I; no grupo II, todos estavam normais. Artérias cerebrais médias foram as únicas acometidas. CONCLUSÃO: Houve baixa prevalência de resultados anormais ao DTC em pacientes com DF. A VMMáx foi significativamente diferente entre os genótipos da DF e apresentou correlação com variáveis hematológicas. pt
dc.format.extent 134-138
dc.language.iso eng
dc.publisher Associação Paulista de Medicina - APM
dc.relation.ispartof São Paulo Medical Journal
dc.rights Acesso aberto
dc.subject Ultrasonography, Doppler, transcranial en
dc.subject Anemia, sickle cell en
dc.subject Hemoglobin SC disease en
dc.subject Stroke en
dc.subject Child en
dc.subject Adolescent en
dc.subject Ultrassonografia Doppler transcraniana pt
dc.subject Anemia falciforme pt
dc.subject Doença da hemoglobina SC pt
dc.subject Acidente cerebral vascular pt
dc.subject Criança pt
dc.subject Adolescente pt
dc.title Results from transcranial Doppler examination on children and adolescents with sickle cell disease and correlation between the time-averaged maximum mean velocity and hematological characteristics: a cross-sectional analytical study en
dc.title.alternative Resultados do estudo do Doppler transcraniano em crianças e adolescentes portadores de doença falciforme e correlação entre a velocidade média máxima e características hematológicas: um estudo transversal analítico pt
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Department of Pediatrics
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Department of Neurology
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Department of Pediatrics Division of Pediatric Hematology
dc.description.affiliationUnifesp UNIFESP, Department of Pediatrics
dc.description.affiliationUnifesp UNIFESP, Department of Neurology
dc.description.affiliationUnifesp UNIFESP, Department of Pediatrics Division of Pediatric Hematology
dc.identifier.file S1516-31802011000300003.pdf
dc.identifier.scielo S1516-31802011000300003
dc.identifier.doi 10.1590/S1516-31802011000300003
dc.description.source SciELO
dc.identifier.wos WOS:000292746700003



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