Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

Author Favacho, Hugo Alexandre Silva Google Scholar
Oliveira, Bianca R. Google Scholar
Santos, Kelem Costa dos Google Scholar
Medeiros, Benedito Junior Lima de Google Scholar
Sousa, Pergentino Jose da Cunha Google Scholar
Perazzo, Fábio Ferreira Autor UNIFESP Google Scholar
Carvalho, José Carlos Tavares Google Scholar
Institution Universidade Federal do Amapá Laboratório de Pesquisa em Fármacos
Universidade Federal do Pará Faculdade de Farmácia Programa de Pós-graduação em Ciências Farmacêuticas
Universidade Federal do Pará Faculdade de Farmácia Laboratório de Farmacodinâmica
Universidade Federal de São Paulo (UNIFESP)
Abstract The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.
Keywords Euterpe oleracea Mart.
oil
açaí berry
inflammatory
nociceptive
Arecaceae
Language English
Date 2011-02-01
Published in Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 1, p. 105-114, 2011.
ISSN 0102-695X (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira de Farmacognosia
Extent 105-114
Origin http://dx.doi.org/10.1590/S0102-695X2011005000007
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000289152900018
SciELO ID S0102-695X2011000100018 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6279

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