Improving the outcomes of elderly patients with acute myeloid leukemia in a Brazilian University Hospital

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dc.contributor.author Sandes, Alex Freire [UNIFESP]
dc.contributor.author Ribeiro, Juliana Correa da Costa [UNIFESP]
dc.contributor.author Barroso, Rodrigo S. [UNIFESP]
dc.contributor.author Silva, Maria R.r. [UNIFESP]
dc.contributor.author Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]
dc.date.accessioned 2015-06-14T13:42:50Z
dc.date.available 2015-06-14T13:42:50Z
dc.date.issued 2011-01-01
dc.identifier http://dx.doi.org/10.1590/S1807-59322011000800005
dc.identifier.citation Clinics. Faculdade de Medicina / USP, v. 66, n. 8, p. 1335-1340, 2011.
dc.identifier.issn 1807-5932
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/6227
dc.description.abstract OBJECTIVE: To evaluate the outcomes of acute myeloid leukemia patients who were older than 60 years of age at the time of diagnosis following the implementation of a treatment algorithm based on age, performance status, and cytogenetic results. METHODS: We retrospectively compared the results of 31 elderly acute myeloid leukemia patients (median age of 74 years) who were treated according to the new algorithm. RESULTS: Fifteen patients with a good performance status and no unfavorable karyotypes were treated with either intensive cytotoxic chemotherapy (<70 years, nine cases) or adapted etoposide, 6-thioguanine and idarubicine (>70 years, six cases); 16 cases with a poor performance status or unfavorable cytogenetics received supportive care only. Six patients achieved a complete remission and two achieved a partial remission after chemotherapy. There were three toxic deaths during induction, two in the adapted etoposide, 6-thioguanine and idarubicine group and one in the intensive cytotoxic chemotherapy group. The overall median survival time was 2.96 months, 1.3 months in the supportive care group, and 4.6 months in the treatment group. CONCLUSIONS: Our results illustrate the importance of treatment guidelines adapted to local resources in an attempt to improve the survival of elderly acute myeloid leukemia patients in developing countries. en
dc.format.extent 1335-1340
dc.language.iso eng
dc.publisher Faculdade de Medicina / USP
dc.relation.ispartof Clinics
dc.rights Acesso aberto
dc.subject Acute Myeloid Leukemia en
dc.subject Elderly en
dc.subject Intensive Chemotherapy en
dc.subject Adapted ETI en
dc.subject Prognosis en
dc.title Improving the outcomes of elderly patients with acute myeloid leukemia in a Brazilian University Hospital en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Patologia
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Patologia
dc.identifier.file S1807-59322011000800005.pdf
dc.identifier.scielo S1807-59322011000800005
dc.identifier.doi 10.1590/S1807-59322011000800005
dc.description.source SciELO
dc.identifier.wos WOS:000294822800005



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