Improving the outcomes of elderly patients with acute myeloid leukemia in a Brazilian University Hospital

Improving the outcomes of elderly patients with acute myeloid leukemia in a Brazilian University Hospital

Author Sandes, Alex Freire Autor UNIFESP Google Scholar
Ribeiro, Juliana Correa da Costa Autor UNIFESP Google Scholar
Barroso, Rodrigo S. Autor UNIFESP Google Scholar
Silva, Maria R.r. Autor UNIFESP Google Scholar
Chauffaille, Maria de Lourdes Lopes Ferrari Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE: To evaluate the outcomes of acute myeloid leukemia patients who were older than 60 years of age at the time of diagnosis following the implementation of a treatment algorithm based on age, performance status, and cytogenetic results. METHODS: We retrospectively compared the results of 31 elderly acute myeloid leukemia patients (median age of 74 years) who were treated according to the new algorithm. RESULTS: Fifteen patients with a good performance status and no unfavorable karyotypes were treated with either intensive cytotoxic chemotherapy (<70 years, nine cases) or adapted etoposide, 6-thioguanine and idarubicine (>70 years, six cases); 16 cases with a poor performance status or unfavorable cytogenetics received supportive care only. Six patients achieved a complete remission and two achieved a partial remission after chemotherapy. There were three toxic deaths during induction, two in the adapted etoposide, 6-thioguanine and idarubicine group and one in the intensive cytotoxic chemotherapy group. The overall median survival time was 2.96 months, 1.3 months in the supportive care group, and 4.6 months in the treatment group. CONCLUSIONS: Our results illustrate the importance of treatment guidelines adapted to local resources in an attempt to improve the survival of elderly acute myeloid leukemia patients in developing countries.
Keywords Acute Myeloid Leukemia
Elderly
Intensive Chemotherapy
Adapted ETI
Prognosis
Language English
Date 2011-01-01
Published in Clinics. Faculdade de Medicina / USP, v. 66, n. 8, p. 1335-1340, 2011.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
Publisher Faculdade de Medicina / USP
Extent 1335-1340
Origin http://dx.doi.org/10.1590/S1807-59322011000800005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000294822800005
SciELO ID S1807-59322011000800005 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6227

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