Angiomirs expression profiling in diffuse large B-Cell lymphoma

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dc.contributor.author Borges, Natalia M. [UNIFESP]
dc.contributor.author Elias, Marcela do Vale [UNIFESP]
dc.contributor.author Fook-Alves, Veruska L. [UNIFESP]
dc.contributor.author Andrade, Tathiana A. [UNIFESP]
dc.contributor.author de Conti, Marina Lourenco [UNIFESP]
dc.contributor.author Macedo, Mariana Petaccia
dc.contributor.author Begnami, Maria Dirlei
dc.contributor.author Campos, Antonio Hugo J. F. M.
dc.contributor.author Etto, Leina Yukari [UNIFESP]
dc.contributor.author Bortoluzzo, Adriana Bruscato
dc.contributor.author Alves, Antonio C. [UNIFESP]
dc.contributor.author Young, Ken H.
dc.contributor.author Colleoni, Gisele W. B. [UNIFESP]
dc.date.accessioned 2020-11-03T14:40:40Z
dc.date.available 2020-11-03T14:40:40Z
dc.date.issued 2016
dc.identifier https://doi.org/10.18632/oncotarget.6624
dc.identifier.citation Oncotarget. Orchard Park, v. 7, n. 4, p. 4806-4816, 2016.
dc.identifier.issn 1949-2553
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/58673
dc.description.abstract Despite advances in treatment, 30% of diffuse large B-cell lymphoma (DLBCL) cases are refractory or relapse after chemoimmunotherapy. Currently, the relationship between angiogenesis and angiomiRs in DLBCL is unknown. We classified 84 DLBCL cases according to stromal signatures and evaluated the expression of pro-and antiangiomiRs in paraffin embedded tissues of DLBCL and correlated them with microvascular density (MVD). 40% of cases were classified as stromal-1, 50% as stromal-2 and 10% were not classified. We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378 in 14%, 57%, 30%, 45%, 12%, 12%, 56%, 58% and 48% of the cases, respectively. Among antiangiomiRs we found decreased expression of miR-16, miR-20b, miR-92a, miR-221 and miR-328 in, respectively, 27%, 71%, 2%, 44% and 11%. We found association between increased expression of proangiomiRs miR-126 and miR-130a and antiangiomiR miR-328 and the subtype non-GCB. We found higher levels of the antiangiomiRs miR-16, miR-221 and miR-328 in patients with low MVD and stromal-1 signature. IPI and CD34 confirmed independent impact on survival of the study group. None of the above angiomiRs showed significance as biomarker in an independent serum samples cohort of patients and controls. In conclusion, we confirmed association between antiangiomiRs miR-16, miR-221 and miR-328 and stromal-1 signature. Four angiomiRs emerged as potential therapeutic targets: proangiomiRs miR-17, miR-210 and miR-296 and antiangiomiR miR-20b. Although the four microRNAs seem to be important in DLBCL pathogenesis, they were not predictive of DLBCL onset or relapse in the serum independent cohort. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil
dc.format.extent 4806-4816
dc.language.iso eng
dc.publisher Impact Journals Llc
dc.relation.ispartof Oncotarget
dc.rights Acesso aberto
dc.subject lymphoma en
dc.subject angiogenesis en
dc.subject microRNAs en
dc.title Angiomirs expression profiling in diffuse large B-Cell lymphoma en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, Brazil
dc.description.affiliation AC Camargo Canc Ctr, Sao Paulo, Brazil
dc.description.affiliation Insper Inst Educ & Res, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Patol, Sao Paulo, Brazil
dc.description.affiliation Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Patol, Sao Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2010/17668-6
dc.identifier.file WOS000369952400086.pdf
dc.identifier.doi 10.18632/oncotarget.6624
dc.description.source Web of Science
dc.identifier.wos WOS:000369952400086
dc.coverage Orchard Park
dc.citation.volume 7
dc.citation.issue 4



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