NREM-related parasomnias in Machado-Joseph disease: clinical and polysomnographic evaluation

NREM-related parasomnias in Machado-Joseph disease: clinical and polysomnographic evaluation

Author Fontes Silva, Giselle Melo Autor UNIFESP Google Scholar
Pedroso, Jose Luiz Autor UNIFESP Google Scholar
Dos Santos, Diogo Fernandes Autor UNIFESP Google Scholar
Braga-Neto, Pedro Autor UNIFESP Google Scholar
Prado, Lucila Bizari Fernandes Do Autor UNIFESP Google Scholar
Carvalho, Luciane Bizari Coin De Autor UNIFESP Google Scholar
Barsottini, Orlando G. P. Autor UNIFESP Google Scholar
Do Prado, Gilmar Fernandes Autor UNIFESP Google Scholar
Abstract Spinocerebellar ataxias (SCA) are autosomal dominant neurodegenerative disorders that affect the cerebellum and its connections, and have a marked clinical and genetic variability. Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3)MJD/SCA3is the most common SCA worldwide. MJD/SCA3 is characterized classically by progressive ataxia and variable other motor and non-motor symptoms. Sleep disorders are common, and include rapid eye movement (REM) sleep behaviour disorder (RBD), restless legs syndrome (RLS), insomnia, excessive daytime sleepiness, excessive fragmentary myoclonus and sleep apnea. This study aims to focus upon determining the presence or not of non-REM (NREM)-related parasomnias in MJD/SCA 3, using data from polysomnography (PSG) and clinical evaluation. Forty-seven patients with clinical and genetic diagnosis of MJD/SCA3 and 47 control subjects were evaluated clinically and by polysomnography. MJD/SCA3 patients had a higher frequency of arousals from slow wave sleep (P<0.001), parasomnia complaints (confusional arousal/sleep terrors, P=0.001; RBD, P<0.001; and nightmares, P<0.001), REM sleep without atonia (P<0.001), periodic limb movements of sleep index (PLMSi) (P<0.001), percentage of N3 sleep (P<0.001) and percentage of N1 sleep (P<0.001). These data show that NREM-related parasomnias must be included in the spectrum of sleep disorders in MJD/SCA3 patients.
Keywords Machado-Joseph disease
NREM-related parasomnias
sleep disorders
spinocerebellar ataxia type 3
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Date 2016
Published in Journal Of Sleep Research. Hoboken, v. 25, n. 1, p. 11-15, 2016.
ISSN 0962-1105 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 11-15
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000367618900003

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