Differences in Corneal Parameters Between Affected and Normal Contralateral Eyes in Patients With Hemifacial Spasm Treated With Botulinum Toxin-A: Outcomes During One Complete Treatment Cycle

Differences in Corneal Parameters Between Affected and Normal Contralateral Eyes in Patients With Hemifacial Spasm Treated With Botulinum Toxin-A: Outcomes During One Complete Treatment Cycle

Author Osaki, Teissy Autor UNIFESP Google Scholar
Osaki, Midori H. Autor UNIFESP Google Scholar
Osaki, Tammy H. Autor UNIFESP Google Scholar
Hirai, Flavio E. Autor UNIFESP Google Scholar
Campos, Mauro Autor UNIFESP Google Scholar
Abstract Purpose:To investigate possible temporary differences in corneal topographic parameters between affected and normal eyes in patients with hemifacial spasm (HFS) treated with botulinum toxin-A (BTX-A), over the course of 1 treatment cycle.Methods:This prospective study evaluated corneal topographic differences between affected and normal contralateral eyes during a 4-month period in patients with HFS treated with BTX-A (the duration of action of BTX-A for HFS ranges from 2 to 4 months). Corneal topographic analysis was performed using a conventional topographer (Atlas; Carl Zeiss Meditec, Dublin, CA). Steep K and astigmatism measurements were evaluated before BTX-A application and after 15 days and 2, 3, and 4 months.Results:Twenty-four patients (16 women and 8 men) were evaluated. Steep K [46.9 3.6 diopters (D)] and astigmatism values (2.6 +/- 2.5 D) were significantly higher in affected eyes of HFS patients than in nonaffected eyes (45.0 +/- 1.4 D and 0.9 +/- 0.6 D) before treatment (P = 0.001 for steep K and P = 0.0003 for astigmatism). Astigmatism values also showed significant differences between the affected eye (1.4 +/- 0.8 D) and nonaffected eye (0.9 +/- 0.6 D) at 4 months (P = 0.006), whereas steep K showed significant differences between both eyes at 15 days (affected eye: 45.6 +/- 1.5 D, nonaffected eye: 45.0 +/- 1.4 D, P = 0.008), 3 months (affected eye: 45.6 +/- 1.8 D, nonaffected eye: 45.1 +/- 1.3 D, P = 0.03) and 4 months (affected eye: 45.8 +/- 1.2 D, nonaffected eye: 45.1 +/- 1.4 D, P = 0.003) after treatment.Conclusions:The differences in steep K, and especially in astigmatism values, between eyes tended to reduce during the period of action of BTX-A. At 4 months, when the BTX-A effect is considered to be over or very reduced, a significant difference between eyes for both parameters was noted again.
Keywords hemifacial spasm
astigmatism
steep K
corneal topography
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Sponsor Brazilian National Research Council-CAPES
Date 2016
Published in Cornea. Philadelphia, v. 35, n. 2, p. 220-225, 2016.
ISSN 0277-3740 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 220-225
Origin https://doi.org/10.1097/ICO.0000000000000688
Access rights Closed access
Type Article
Web of Science ID WOS:000368803200015
URI https://repositorio.unifesp.br/handle/11600/58648

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