Cardiovascular and metabolic risk markers are related to parasympathetic indices in pre-pubertal adolescents

Cardiovascular and metabolic risk markers are related to parasympathetic indices in pre-pubertal adolescents

Author Cayres, Suziane U. Google Scholar
Vanderlei, Luiz Carlos M. Google Scholar
Silva, Danilo R. P. Google Scholar
Lima, Manoel Carlos S. Google Scholar
Barbosa, Mauricio F. Autor UNIFESP Google Scholar
Fernandes, Romulo A. Google Scholar
Abstract Objective To analyse the relationship between different heart rate variability indices, resting heart rate, and cardiovascular markers in adolescents. Methods A cross-sectional study was carried out with information from an ongoing cohort study. The sample was composed of 99 adolescents who complied with the following inclusion criteria: aged between 11 and 14 years; enrolled in a school unit of elementary education; absence of any known diseases; no drug consumption; and a formal consent signed by the parents or legal guardians. Weight, height, heart rate variability, lipid profile, inflammatory markers, blood pressure, resting heart rate, intima-media thickness, blood flow, and trunk fatness were measured. Partial correlation and linear regression (expressed by and 95% confidence intervals [95%CI]) analyses were used to analyse the relationships between the variables. Results In the linear regression analysis, even after adjustments for sex, age, trunk fatness, and somatic maturation, parasympathetic activity presented significant correlations with maximum carotid artery blood flow (=-0.111 [95%CI=-0.216; -0.007]), systolic blood pressure (=-0.319 [95%CI=-0.638; -0.001]), and resting heat rate (=-0.005 [95%CI=-0.009; -0.002]). Conclusion Parasympathetic activity at rest is inversely related to maximum and minimum blood flow, triacylglycerol levels, and systolic blood pressure. These findings suggest that heart rate variability has the potential to discriminate pre-pubertal adolescents at increased risk.
Keywords Children
atherosclerosis
heart rate variability
cardiovascular risk
xmlui.dri2xhtml.METS-1.0.item-coverage Cambridge
Language English
Sponsor State of Sao Paulo Research Support Foundation (FAPESP)
CNPq
Grant number FAPESP: 2013/06052-2
CNPq: 476295/2013-0
Date 2016
Published in Cardiology In The Young. Cambridge, v. 26, n. 2, p. 280-287, 2016.
ISSN 1047-9511 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 280-287
Origin https://doi.org/10.1017/S1047951115000141
Access rights Closed access
Type Article
Web of Science ID WOS:000369084000009
URI https://repositorio.unifesp.br/handle/11600/58621

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