Human papillomavirus detected in viral warts of renal transplant recipients

Human papillomavirus detected in viral warts of renal transplant recipients

Author Martelli-Marzagao, F. Autor UNIFESP Google Scholar
Santos Junior, G. F. Google Scholar
Ogawa, M. M. Autor UNIFESP Google Scholar
Enokihara, M. M. S. S. Autor UNIFESP Google Scholar
Porro, A. M. Autor UNIFESP Google Scholar
Tomimori, J. Autor UNIFESP Google Scholar
Abstract ObjectivesFew studies have been conducted in South America regarding the detection and genotyping of human papillomavirus (HPV) in viral warts of renal transplant recipients (RTRs). The characterization of the population most susceptible to the development of warts and the knowledge of the main HPV types in this environment prompted this study, which focuses on the detection and typing of HPV in RTRs in Brazil. MethodsFifty-eight patients with viral warts from the Hospital SAo Paulo/Federal University of SAo Paulo were included in this study. HPV was detected by polymerase chain reaction (PCR) using combinations of the following primers: PGMY 09/11, RK 91, CP 65/70, and CP 66/69. Restriction fragment length polymorphism and automated sequencing techniques were used for HPV typing. ResultsHPV was detected by PCR in 89.7% of viral wart samples. The most frequently detected HPV types included 57, 27, 1a, 2a, and 20. Other types of HPV-epidermodysplasia verruciformis were also detected, including 14, 15, 19, 20, 21, 23, 36, and 38. Rare HPV types were also detected in our environment, including RTR X1, RTR X7, and 100. The time after transplant was correlated with an increased number of lesions and beta papillomavirus genus infection. ConclusionsThe HPV types detected in the RTR population were similar to those described in immunocompetent populations. However, the diversity of the HPV types identified and the number of lesions were increased in the RTR population.
Keywords HPV
renal transplantation
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Date 2016
Published in Transplant Infectious Disease. Hoboken, v. 18, n. 1, p. 37-43, 2016.
ISSN 1398-2273 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 37-43
Access rights Closed access
Type Article
Web of Science ID WOS:000370449800005

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