Experimental maxillary sinus augmentation using a highly bioactive glass ceramic

Experimental maxillary sinus augmentation using a highly bioactive glass ceramic

Author Vivan, Rodrigo Ricci Google Scholar
Mecca, Carlos Eduardo Google Scholar
Biguetti, Claudia Cristina Google Scholar
Renno, Ana Claudia Muniz Autor UNIFESP Google Scholar
Okamoto, Roberta Google Scholar
Cavenago, Bruno Cavalini Google Scholar
Duarte, Marco Hungaro Google Scholar
Matsumoto, Mariza Akemi Google Scholar
Abstract Physicochemical characteristics of a biomaterial directly influence its biological behavior and fate. However, anatomical and physiological particularities of the recipient site also seem to contribute with this process. The present study aimed to evaluate bone healing of maxillary sinus augmentation using a novel bioactive glass ceramic in comparison with a bovine hydroxyapatite. Bilateral sinus augmentation was performed in adult male rabbits, divided into 4 groups according to the biomaterial used: BO-particulate bovine HA Bio-Oss (R) (BO), BO? G-particulate bovine HA ? particulate autogenous bone graft (G), BS-particulate glass ceramic (180-212 mu m) Biosilicate (R) (BS), and BS+G-particulate glass ceramic + G. After 45 and 90 days, animals were euthanized and the specimens prepared to be analyzed under light and polarized microscopy, immunohistochemistry, scanning electron microscopy (SEM), and micro-computed tomography (mu CT). Results revealed different degradation pattern between both biomaterials, despite the association with bone graft. BS caused a more intense chronic inflammation with foreign body reaction, which led to a difficulty in bone formation. Besides this evidence, SEM and mu CT confirmed direct contact between newly formed bone and biomaterial, along with osteopontin and osteocalcin immunolabeling. Bone matrix mineralization was late in BS group but became similar to BO at day 90. These results clearly indicate that further studies about Biosilicate (R) are necessary to identify the factors that resulted in an unfavorable healing response when used in maxillary sinus augmentation.
xmlui.dri2xhtml.METS-1.0.item-coverage Dordrecht
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP/SP)
Grant number FAPESP: 2008/11485-8
FAPESP: 2009/17294-1
Date 2016
Published in Journal Of Materials Science-Materials In Medicine. Dordrecht, v. 27, n. 2, p. -, 2016.
ISSN 0957-4530 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent -
Origin https://doi.org/10.1007/s10856-015-5652-7
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000368726300020
URI https://repositorio.unifesp.br/handle/11600/58507

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