Towards a better understanding of the clinical association of anti-DFS70 autoantibodies

Towards a better understanding of the clinical association of anti-DFS70 autoantibodies

Author Mahler, Michael Google Scholar
Meroni, Pier Luigi Google Scholar
Andrade, Luis E. Autor UNIFESP Google Scholar
Khamashta, Munther Google Scholar
Bizzaro, Nicola Google Scholar
Casiano, Carlos A. Google Scholar
Fritzler, Marvin J. Google Scholar
Abstract Anti-DFS70 antibodies and their clinical associations remain an immunological paradox. Unlike other antinuclear antibodies (ANA), especially when present at high titres, anti-DFS70 antibodies are not prevalent in ANA associated rheumatic diseases. Despite significant interest and progress in understanding the clinical association of anti-DFS70 antibodies, no specific clinical associations have been confirmed. In reality, several studies reporting clinical association of these antibodies (i.e. atopic dermatitis, thrombosis, autoimmune thyroiditis) have added confusion instead of bringing significant insight. In addition, several groups have consistently reported on the occurrence of anti-DFS70 antibodies in a relevant fraction of apparently healthy individuals. This review aims to analyse the current knowledge and to provide future guidance to analyse potential clinical associations of anti-DFS70 antibodies by summarizing and interpreting recent findings. (C) 2015 Elsevier B.V. All rights reserved.
Keywords Antinuclear antibodies
DFS
LEDGF
Autoantibodies
Autoimmune diseases
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Inova Diagnostics
Date 2016
Published in Autoimmunity Reviews. Amsterdam, v. 15, n. 2, p. 198-201, 2016.
ISSN 1568-9972 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 198-201
Origin https://doi.org/10.1016/j.autrev.2015.11.006
Access rights Closed access
Type Article
Web of Science ID WOS:000368747900011
URI https://repositorio.unifesp.br/handle/11600/58503

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