Egg donation of vitrified oocytes bank produces similar pregnancy rates by blastocyst transfer when compared to fresh cycle

Egg donation of vitrified oocytes bank produces similar pregnancy rates by blastocyst transfer when compared to fresh cycle

Author Domingues, Thais S. Autor UNIFESP Google Scholar
Aquino, Ana Paula Google Scholar
Barros, Bruna Google Scholar
Mazetto, Raquel Google Scholar
Nicolielo, Mariana Google Scholar
Kimati, Carolina M. Google Scholar
Devecchi, Talita Google Scholar
Bonetti, Tatiana C. S. Autor UNIFESP Google Scholar
Serafini, Paulo C. Google Scholar
Motta, Eduardo L. A. Autor UNIFESP Google Scholar
Abstract Purpose Advances in reproductive techniques, mainly the introduction of oocyte vitrification, have provided the opportunity to conceive from oocyte banks. The aim of this study was to compare the clinical outcomes of fresh and vitrified oocytes in an egg donation program following blastocyst transfer. Methods This retrospective observational study included 504 oocyte donation cycles. All donor women were younger than 30 years of age. The recipient cycles were divided into two groups: fresh oocytes (n = 78) or vitrified oocytes (n = 426). All oocytes were fertilized by ICSI using ejaculated sperm, followed by blastocyst transfer. Endometrium preparation was performed with estradiol valerate plus micronized progesterone according to standard protocols. Results Recipients were of similar age (fresh 42.0 +/- 4.5 years vs vitrified 41.8 +/- 4.8 years; p = 0.790). The fresh group received more mature oocytes for injection compared to the vitrified group (10.1 +/- 2.8 vs 9.2 +/- 2.2; p = 0.005). The two pronuclei (2PN) rate (74.5 vs 77.4%; p = 0.195) and blastocyst rate (48.8 vs 51.6%; 0.329) were similar between the fresh and vitrified groups, respectively. The rates of clinical pregnancy were 60.9% in the fresh and 59.0% in the vitrified groups (p = 0.771). Conclusions Our findings suggest that vitrified oocytes result in similar pregnancy rates when compared to fresh oocytes with blastocyst transfer in an egg donation program. Moreover, vitrified oocytes may allow for a better cycle schedule, starting with a lower number of oocytes to be fertilized. Therefore, we hypothesize that egg banks with vitrified oocytes could be safely utilized in an egg donation program.
Keywords Oocyte donation
Oocyte vitrification
In vitro fertilization
Blastocyst transfer
Pregnancy rates
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Date 2017
Published in Journal Of Assisted Reproduction And Genetics. New York, v. 34, n. 11, p. 1553-1557, 2017.
ISSN 1058-0468 (Sherpa/Romeo, impact factor)
Publisher Springer/Plenum Publishers
Extent 1553-1557
Origin http://dx.doi.org/10.1007/s10815-017-1017-0
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000416159300020
URI https://repositorio.unifesp.br/handle/11600/58259

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