CA1 inactivation impairs episodic-like memory in rats

CA1 inactivation impairs episodic-like memory in rats

Author Drieskens, Davi Carvalho Google Scholar
Neves, Livia Rodrigues Google Scholar
Pugliane, Karen Cristina Google Scholar
Montenegro Bento de Souza, Ingrid Brasilino Google Scholar
Lima, Alvaro da Costa Autor UNIFESP Google Scholar
da Silva Stiebbe Salvadori, Mirian Graciela Google Scholar
Ribeiro, Alessandra Mussi Autor UNIFESP Google Scholar
Silva, Regina Helena Autor UNIFESP Google Scholar
Barbosa, Flavio Freitas Google Scholar
Abstract Episodic memory was initially believed to be unique to humans. However, studies demonstrate that non-human species discriminate items based on the triad what, where and when. Here we addressed the role of the dorsal hippocampal subfield CA1 in an integrative what-where-when task in Wistar rats. We performed bilateral inactivation of dorsal CA1 with the GABAA agonist muscimol previously to the task. As expected, sham-operated animals recollected an integrative memory for objects (what), their places (where) and temporal order (when). However, the inactivation of CA1 impaired the performance of the three components of episodic-like memory. In addition, total time of objects exploration and distance traveled were not different between groups, indicating that rats had similar levels of motivation, thus, alterations in exploration does not account for impaired locomotor performance. Altogether, our data provides evidence that CA1 plays an important role in episodic-like memory. (C) 2017 Elsevier Inc. All rights
Keywords Episodic-like memory
CA1
Muscimol
Wistar rats
xmlui.dri2xhtml.METS-1.0.item-coverage San Diego
Language English
Sponsor Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Grant number CNPq: 014/2013 - Universal
Date 2017
Published in Neurobiology Of Learning And Memory. San Diego, v. 145, p. 28-33, 2017.
ISSN 1074-7427 (Sherpa/Romeo, impact factor)
Publisher Academic Press Inc Elsevier Science
Extent 28-33
Origin http://dx.doi.org/10.1016/j.nlm.2017.08.008
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000417115800004
URI https://repositorio.unifesp.br/handle/11600/58247

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