Relationship between Anxiety and Interleukin 10 in Female Soccer Players with and Without Premenstrual Syndrome (PMS)

Relationship between Anxiety and Interleukin 10 in Female Soccer Players with and Without Premenstrual Syndrome (PMS)

Author Foster, Roberta Autor UNIFESP Google Scholar
Vaisberg, Mauro Autor UNIFESP Google Scholar
de Araujo, Maita Poli Autor UNIFESP Google Scholar
Martins, Marcia Aparecida Autor UNIFESP Google Scholar
Capel, Tiago Autor UNIFESP Google Scholar
Lacerda Bachi, Andre Luis Google Scholar
Katalin de Jarmy-Di Bella, Zsuzsanna Ilona Autor UNIFESP Google Scholar
Abstract Objective To investigate the level of anxiety and its relationship with interleukin (IL)10 (anti inflammatory cytokine that modulates mood swings) in a group of female soccer players. Methods Fifty-two eumenorrheic soccer players were evaluated (age 19.8 +/- 4.7 years). The presence of premenstrual syndrome (PMS) and phases of the menstrual cycle were determined by a daily symptomreport (DSR) kept for 3 consecutivemonths. The concentration of cytokine IL-10 was determined from urine samples collected at four moments: at the follicular and luteal phases of the menstrual cycle, and before (pre) and after (post) the simulated game, and it was quantified by flow cytometry (Luminex xMAP - EMDMillipore, Billerica, MA, USA). The level of anxietywas determined through the BAI anxiety questionnaire answered by all athletes at the same time of the urine collection. The Student t-test, analysis of variance (ANOVA) and Pearson correlation with significance level at 5% were used for data analysis. Results We showed that the prevalence of PMS among female soccer players is similar to that reported in the literature. In addition, we showed that the group withPMS has a higher level of anxiety compared with group without PMS (p = 0.002). Interleukin-10 analysis in players without PMS revealed that there was a significant decrease in the level of this cytokine before the game during the luteal phase when compared with the follicular phase (p < 0.05). The correlation analysis between IL-10 and anxiety showed a negative correlation post-game in the luteal phase in the group without PMS (p = 0.02; r = -0.50) and a positive correlation post-game in the luteal phase in PMS group (p = 0.04; r = 0.36). Conclusion Our results suggest that IL-10 may contribute to reduce anxiety in the group without PMS. This could be attributed to the fact that no IL-10 variation was observed in the group with PMS, which presented higher anxiety symptoms when compared with the group without PMS.
Keywords soccer
menstrual cycle
premenstrual syndrome
xmlui.dri2xhtml.METS-1.0.item-coverage Rio De Janeiro Rj
Language English
Sponsor Fundacao e Amparo a Pesquisa do Estado de Sao Paulo - FAPESP
Grant number FAPESP: 10/52424
Date 2017
Published in Revista Brasileira De Ginecologia E Obstetricia. Rio De Janeiro Rj, v. 39, n. 11, p. 602-607, 2017.
ISSN 0100-7203 (Sherpa/Romeo, impact factor)
Publisher Federacao Brasileira Soc Ginecologia & Obstetricia-Febrasgo
Extent 602-607
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000418071900004
SciELO ID S0100-72032017001100602 (statistics in SciELO)

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