A preliminary study of bipolar disorder type I by mass spectrometry-based serum lipidomics

A preliminary study of bipolar disorder type I by mass spectrometry-based serum lipidomics

Author Ribeiro, Henrique C. Google Scholar
Klassen, Aline Autor UNIFESP Google Scholar
Pedrini, Mariana Autor UNIFESP Google Scholar
Carvalho, Michelle S. Autor UNIFESP Google Scholar
Rizzo, Lucas B. Autor UNIFESP Google Scholar
Noto, Mariane N. Autor UNIFESP Google Scholar
Zeni-Graiff, Maiara Autor UNIFESP Google Scholar
Sethi, Sumit Autor UNIFESP Google Scholar
Fonseca, Francisco A. H. Autor UNIFESP Google Scholar
Tasic, Ljubica Google Scholar
Hayashi, Mirian A. F. Autor UNIFESP Google Scholar
Cordeiro, Quirino Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Sussulini, Alessandra Google Scholar
Abstract The present study aimed at investigating possible alterations in the serum lipid profile of euthymic patients with bipolar disorder type I (BD) compared to healthy controls (HC). Thirty-five individuals from both genders were recruited, with 14 diagnosed and treated as BD patients (BD group) and 21 healthy subjects (HC group). Clinical assessment was based on the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Young Mania Rating Scale (YMRS), and 17-items of Hamilton Depression Rating Scale (HDRS-17) data, which were used to confirm diagnosis, to verify psychiatric comorbidities, and to estimate the severity of manic and depressive symptoms. Ultra-high performance liquid chromatography (UHPLC) coupled to high resolution mass spectrometry (HRMS) was applied to analyze the lipids extracted from all serum samples from both studied groups. In this pioneer and exploratory study, we observed different serum lipid profiles for BD and HC groups, especially regarding glycerophospholipid, glycerolipid, and sphingolipid distribution. Multivariate statistical analyses indicated that 121 lipids were significantly different between BD and HC. Phosphatidylinositols were identified as the most altered lipids in BD patient sera. The results of this preliminary study reinforce the role of lipid abnormalities in BD and offer additional methodological possibilities for investigation in the field.
Keywords Metabolomics
Mood disorders
Ultra-high performance liquid chromatography
Untargeted lipid analysis
Blood serum samples
xmlui.dri2xhtml.METS-1.0.item-coverage Clare
Language English
Sponsor FAPESP
Grant number FAPESP: 2014/18938-8
FAPESP: 2015/13229-1
FAEPEX: 1244/14
Date 2017
Published in Psychiatry Research. Clare, v. 258, p. 268-273, 2017.
ISSN 0165-1781 (Sherpa/Romeo, impact factor)
Publisher Elsevier Ireland Ltd
Extent 268-273
Origin http://dx.doi.org/10.1016/j.psychres.2017.08.039
Access rights Closed access
Type Article
Web of Science ID WOS:000416184500043
URI https://repositorio.unifesp.br/handle/11600/58134

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