Why averaging multiple MUNIX measures in the longitudinal assessment of patients with ALS?

Why averaging multiple MUNIX measures in the longitudinal assessment of patients with ALS?

Author Escorcio-Bezerra, Marcio Luiz Autor UNIFESP Google Scholar
Abrahao, Agessandro Autor UNIFESP Google Scholar
Santos-Neto, Denizart Autor UNIFESP Google Scholar
de Oliveira Braga, Nadia Iandoli Autor UNIFESP Google Scholar
Bulle Oliveira, Acary Souza Autor UNIFESP Google Scholar
Manzano, Gilberto Mastrocola Autor UNIFESP Google Scholar
Abstract Objective: To assess the impact of averaging multiple MUNIX trials on the follow-up of patients with amyotrophic lateral sclerosis (ALS).& para;& para;Methods: We determined the percent relative change (%RC) of MUNIX, in healthy subjects and patients with ALS, by subtracting the MUNIX value in the second visit from the first. Both the mean of a set of three MUNIX (mean-MUNIX) and the first MUNIX sample (single-MUNIX) were evaluated. Then, we studied the sensitivity to detect relative changes over time and the statistical dispersion of the %RC from these two parameters.& para;& para;Results: We found that the mean-MUNIX %RC has lower mean coefficient of variation than the single-MUNIX %RC in all muscles. The mean-MUNIX also resulted in more ALS patients with significant %RC, i.e., outside reference limits.& para;& para;Conclusion: The mean-MUNIX resulted in less dispersed values of %RC in patients with ALS and thus, increased the precision of the technique. The mean-MUNIX resulted also in an increase in the sensitivity to track changes over time in these patients.& para;& para;Significance: The mean-MUNIX should be considered in any ALS follow-up study as a more reliable approach and as a way of potentially reducing the sample size needed for the study. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Keywords MUNIX
ALS
Reproducibility
Precision
Motor neuron disease
Motor unit
Motor unit number index
xmlui.dri2xhtml.METS-1.0.item-coverage Clare
Language English
Date 2017
Published in Clinical Neurophysiology. Clare, v. 128, n. 12, p. 2392-2396, 2017.
ISSN 1388-2457 (Sherpa/Romeo, impact factor)
Publisher Elsevier Ireland Ltd
Extent 2392-2396
Origin http://dx.doi.org/10.1016/j.clinph.2017.09.104
Access rights Closed access
Type Article
Web of Science ID WOS:000415788600005
URI https://repositorio.unifesp.br/handle/11600/58125

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