Sporadic Inclusion Body Myositis: MRI Findings and Correlation With Clinical and Functional Parameters

Sporadic Inclusion Body Myositis: MRI Findings and Correlation With Clinical and Functional Parameters

Author Guimaraes, Julio Brandao Autor UNIFESP Google Scholar
Zanoteli, Edmar Google Scholar
Link, Thomas M. Google Scholar
de Camargo, Leonardo V. Google Scholar
Facchetti, Luca Google Scholar
Artur, Lorenzo Nardo Google Scholar
Correa Fernandes, Artur da Rocha Autor UNIFESP Google Scholar
Abstract OBJECTIVE. The purpose of this prospective study is to assess MRI findings in patients with sporadic inclusion body myositis (IBM) and correlate them with clinical and functional parameters. SUBJECTS AND METHODS. This study included 12 patients with biopsy-proven sporadic IBM. All patients underwent MRI of the bilateral upper and lower extremities. The images were scored for muscle atrophy, fatty infiltration, and edema pattern. Clinical data included onset and duration of disease. Muscle strength was measured using the Medical Research Council (MRC) scale, and functional status was assessed using the Modified Rankin Scale. Correlation between MRI and different clinical and functional parameters was calculated using the Spearman rank test and Pearson correlation. RESULTS. All patients showed MRI abnormalities, which were more severe within the lower limbs and the distal segments. The most prevalent MRI finding was fat infiltration. There was a statistically significant correlation between disease duration and number of muscles infiltrated by fat (r = 0.65; p = 0.04). The number of muscles with fat infiltration correlated with the sum of the scores of MRC (r = -0.60; p = 0.04) and with the Modified Rankin Scale (r = 0.48; p = 0.03). CONCLUSION. Our findings suggest that most patients with biopsy-proven sporadic IBM present with a typical pattern of muscle involvement at MRI, more extensively in the lower extremities. Moreover, MRI findings strongly correlated with clinical and functional parameters, because both the extent and severity of muscle involvement assessed by MRI and clinical and functional parameters are associated with the early onset of the disease and its duration.
Keywords atrophy
fat infiltration
idiopathic myopathy
inflammatory myopathies
MRI
sporadic body inclusion myositis
xmlui.dri2xhtml.METS-1.0.item-coverage Reston
Language English
Date 2017
Published in American Journal Of Roentgenology. Reston, v. 209, n. 6, p. 1340-1347, 2017.
ISSN 0361-803X (Sherpa/Romeo, impact factor)
Publisher Amer Roentgen Ray Soc
Extent 1340-1347
Origin http://dx.doi.org/10.2214/AJR.17.17849
Access rights Closed access
Type Article
Web of Science ID WOS:000415982900038
URI https://repositorio.unifesp.br/handle/11600/58121

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