LEPR polymorphism may affect energy balance during weight loss among Brazilians obese adolescents

LEPR polymorphism may affect energy balance during weight loss among Brazilians obese adolescents

Author Corgosinho, Flavia Campos Autor UNIFESP Google Scholar
Almeida, Sandro Soares Autor UNIFESP Google Scholar
Tock, Lian Google Scholar
Pesquero, João Bosco Autor UNIFESP Google Scholar
Araujo, Ronaldo Carvalho Autor UNIFESP Google Scholar
Clemente, Ana Paula Grotti Google Scholar
Dal Molin Netto, Bárbara Autor UNIFESP Google Scholar
Campos, Raquel Munhoz da Silveira Autor UNIFESP Google Scholar
Masquio, Deborah Cristina Landi Google Scholar
Ferreira, Joana Pereira de Carvalho Autor UNIFESP Google Scholar
Sanches, Priscila de Lima Autor UNIFESP Google Scholar
Piano, Aline de Google Scholar
Rogero, Marcelo Macedo Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Abstract Objective: Leptin is an adipokine released mainly by adipose tissue, with many functions including regulation of energy balance. However, little is known about the effect of LEPR polymorphism on orexigenic and anorexigenic neuropeptides. Thus, the aim of the present study is to verify the influence of LEPR polymorphism (rs2767485) on serum orexigenic (NPY, MCH and AgRP) and anorexigenic (Leptin and alpha-MSH) neuropeptides levels among obese adolescents submitted to 1 year of multicomponent weight loss therapy. Methods: Seventy-six adolescents with obesity were enrolled in 1 year of weight loss therapy including clinical, nutritional, psychological and exercise-related. Blood samples were collected to analyze neuropeptides (NPY, MCH, AgRP and leptin) and LEPR genotyping. Visceral fat was measured by ultrasound and body composition was measured by plethysmography. The parameters were measured at baseline and after one year. Adolescents were grouped according to genotype (TT or CT + CC group). Effect of the weight loss therapy was analyzed through ANOVA and Wilcox, according to normality. Statistic value was set at < 0.05. Results: C-allele carriers have the orexigenic neuropeptides (NPY, AgRP and MCH) levels statistically higher when compared with TT group, at baseline. Furthermore, TT group seems to respond better to the therapy by a greater delta on BMI. Indeed, the data suggest a concomitant increased of AgRP levels in CT + CC genotypes, after weight loss therapy. Conclusion: Both groups responded to the weight loss intervention, however wildtypes (TT) appear to respond to the intervention most optimally with C carries, where post intervention reduction in BMI was significantly greater in wildtypes. The leptin receptor polymorphism seems to affect neuroendocrine regulation of energy balance among adolescents with obesity.
Keywords Leptin
Energy balance
xmlui.dri2xhtml.METS-1.0.item-coverage Edinburgh
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number CAPES: 12880-12-4
FAPESP: 2011/50356-0
FAPESP: 2011/50414-0
FAPESP: 2013/085226
FAPESP: 9814303-3
CNPq: 300654/2013-8
Date 2017
Published in Neuropeptides. Edinburgh, v. 66, p. 18-24, 2017.
ISSN 0143-4179 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 18-24
Origin https://dx.doi.org/10.1016/j.npep.2017.07.007
Access rights Closed access
Type Article
Web of Science ID WOS:000416499000003
URI https://repositorio.unifesp.br/handle/11600/58117

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