Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-alpha/ribavirin therapy

Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-alpha/ribavirin therapy

Author Keppeke, Gerson Dierley Autor UNIFESP Google Scholar
Calise, S. John Google Scholar
Chan, Edward K. L. Google Scholar
Andrade, Luis Eduardo C. Autor UNIFESP Google Scholar
Abstract Chronic inflammation associated with hepatitis C virus (HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon a (IFN-alpha) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies (ANA). Between 20% to 40% of HCV patients treated with IFN-a and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings (RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings (anti-RR) autoantibody production by HCV patients after IFN-alpha/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i. e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5 ' n-monophosphate dehydrogenase 2 (IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin
xmlui.dri2xhtml.METS-1.0.item-coverage Pleasanton
Language English
Sponsor Brazilian government research foundations National Council for Research and Technology
Sao Paulo Government agency Sao Paulo State Research Foundation
Grant number FAPESP: 2011/12448-0
FAPESP: 9028-11-0
FAPESP: 305064/2011-8
FAPESP: 232711/2014-3
Date 2016
Published in World Journal Of Gastroenterology. Pleasanton, v. 22, n. 6, p. 1966-1974, 2016.
ISSN 1007-9327 (Sherpa/Romeo, impact factor)
Publisher Baishideng Publishing Group Inc
Extent 1966-1974
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000368559400005

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