High-fat diet during pregnancy and lactation impairs the cholinergic anti-inflammatory pathway in the liver and white adipose tissue of mouse offspring

High-fat diet during pregnancy and lactation impairs the cholinergic anti-inflammatory pathway in the liver and white adipose tissue of mouse offspring

Author Payolla, Tanyara Baliani Google Scholar
Lemes, Simone Ferreira Google Scholar
de Fante, Thais Google Scholar
Reginato, Andressa Google Scholar
da Silva, Cristiano Mendes Autor UNIFESP Google Scholar
Micheletti, Thayana de Oliveira Google Scholar
Rodrigues, Hosana Gomes Google Scholar
Torsoni, Adriana Souza Autor UNIFESP Google Scholar
Milanski, Marciane Autor UNIFESP Google Scholar
Torsoni, Marcio Alberto Autor UNIFESP Google Scholar
Abstract Cholinergic anti-inflammatory pathway (CAP) prevents inflammatory cytokines production. The main was to evaluate the effect of maternal obesity on cholinergic pathway in the offspring. Female mice were subjected to either standard chow (SC) or high-fat diet (HFD) during pregnancy and the lactation period. After weaning, only male offspring from HFD dams (HFD-O) and from SC dams (SC-O) were fed the SC diet. Key proteins of the CAP were downregulated and serum TNF-alpha was elevated in the HFD-O mice. STAT3 and NF-kappa B activation in HFD-O mice ICV injected with nicotine (agonist) were lower than SC-O mice. Basal cholinesterase activity was upregulated in HFD-O mice in both investigated tissues. Lipopolysaccharide increased TNF-alpha and IL-1 beta expression in the liver and WAT of SC-O mice, but this effect was greater in HFD-O mice. In conclusion these changes exacerbated cytokine production in response to LPS and contributed to the reduced sensitivity of the CAP. (C) 2015 Published by Elsevier Ireland Ltd.
Keywords alpha 7nAChR
Cholinergic anti-inflammatory pathway
LPS
Maternal imprinting
Obese mice
High-fat diet
xmlui.dri2xhtml.METS-1.0.item-coverage Clare
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
CNPq
Grant number FAPESP: 14/18165-9
FAPESP: 13/10706-8
CNPq: 476643/2012-0
Date 2016
Published in Molecular And Cellular Endocrinology. Clare, v. 422, n. C, p. 192-202, 2016.
ISSN 0303-7207 (Sherpa/Romeo, impact factor)
Publisher Elsevier Ireland Ltd
Extent 192-202
Origin http://dx.doi.org/10.1016/j.mce.2015.12.004
Access rights Closed access
Type Article
Web of Science ID WOS:000370886100019
URI https://repositorio.unifesp.br/handle/11600/57973

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