Gastroesophageal Reflux Affects Sleep Quality in Snoring Obese Children

Gastroesophageal Reflux Affects Sleep Quality in Snoring Obese Children

Author Machado, Rodrigo Strehl Autor UNIFESP Google Scholar
Woodley, Frederick W. Google Scholar
Skaggs, Beth Google Scholar
Di Lorenzo, Carlo Google Scholar
Eneli, Ihuoma Google Scholar
Splaingard, Mark Google Scholar
Mousa, Hayat Google Scholar
Abstract Purpose: This study was performed to evaluate the quality of sleep in snoring obese children without obstructive sleep apnea (OSA); and to study the possible relationship between sleep interruption and gastroesophageal reflux (GER) in snoring obese children. Methods: Study subjects included 13 snoring obese children who were referred to our sleep lab for possible sleep-disordered breathing. Patients underwent multichannel intraluminal impedance and esophageal pH monitoring with simultaneous polysomnography. Exclusion criteria included history of fundoplication, cystic fibrosis, and infants under the age of 2 years. Significant association between arousals and awakenings with previous reflux were defined by symptom-association probability using 2-minute intervals. Results: Sleep efficiency ranged from 67-97% (median 81%). A total of 111 reflux episodes (90% acidic) were detected during sleep, but there were more episodes per hour during awake periods after sleep onset than during sleep (median 2.3 vs. 0.6, p=0.04). There were 279 total awakenings during the sleep study; 56 (20.1%) of them in 9 patients (69.2%) were preceded by reflux episodes (55 acid, 1 non-acid). In 5 patients (38.5%), awakenings were significantly associated with reflux. Conclusion: The data suggest that acid GER causes sleep interruptions in obese children who have symptoms of snoring or restless sleep and without evidence of OSA.
Keywords Gastroesophageal reflux
Sleep wake disorders
Electric impedance
Obstructive sleep apnea
xmlui.dri2xhtml.METS-1.0.item-coverage Seoul
Language English
Date 2016
Published in Pediatric Gastroenterology Hepatology & Nutrition. Seoul, v. 19, n. 1, p. 12-19, 2016.
ISSN 2234-8646 (Sherpa/Romeo, impact factor)
Publisher Korean Soc Pediatric Gastroenterology & Nutrition
Extent 12-19
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000407721000002

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