Rate of tuberculosis infection in children and adolescents with household contact with adults with active pulmonary tuberculosis as assessed by tuberculin skin test and interferon-gamma release assays

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dc.contributor.author Ferrarini, M. A. G. [UNIFESP]
dc.contributor.author Spina, F. G. [UNIFESP]
dc.contributor.author Weckx, L. Y. [UNIFESP]
dc.contributor.author Lederman, H. M. [UNIFESP]
dc.contributor.author De Moraes-Pinto, M. I. [UNIFESP]
dc.date.accessioned 2020-08-21T17:00:19Z
dc.date.available 2020-08-21T17:00:19Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1017/S0950268815001727
dc.identifier.citation Epidemiology And Infection. New York, v. 144, n. 4, p. 712-723, 2016.
dc.identifier.issn 0950-2688
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/57937
dc.description.abstract Tuberculosis (TB) infection was evaluated in Brazilian immunocompetent children and adolescents exposed and unexposed (control group) to adults with active pulmonary TB. Both groups were analysed by clinical and radiological assessment, TST, QFT-IT and T-SPOT. TB. The three tests were repeated after 8 weeks in the TB-exposed group if results were initially negative. Individuals with latent tuberculosis infection (LTBI) were treated and tests were repeated after treatment. Fifty-nine TB-exposed and 42 controls were evaluated. Rate of infection was 69.5% and 9.5% for the exposed and control groups, respectively. The exposed group infection rate was 61% assessed by TST, 57.6% by T-SPOT. TB, and 59.3%, by QFT-IT. No active TB was diagnosed. Agreement between the three tests was 83.1% and 92.8% in the exposed and control groups, respectively. In the exposed group, T-SPOT. TB added four TB diagnoses [16%, 95% confidence interval (CI) 1.6-30.4] and QFT-IT added three TB diagnoses (12%, 95% CI 0-24.7) in 25 individuals with negative tuberculin skin test (TST). Risk factors associated to TB infection were contact with an adult with active TB [0-60 days: odds ratio (OR) 6.9; >60 days: OR 27.0] and sleeping in the same room as an adult with active TB (OR 5.2). In Brazilian immunocompetent children and adolescents, TST had a similar performance to interferon-gamma release assays and detected a high rate of LTBI. en
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil
dc.format.extent 712-723
dc.language.iso eng
dc.publisher Cambridge Univ Press
dc.relation.ispartof Epidemiology And Infection
dc.rights Acesso aberto
dc.subject Adolescents en
dc.subject BCG en
dc.subject children en
dc.subject IGRA en
dc.subject latent tuberculosis infection en
dc.subject TST en
dc.title Rate of tuberculosis infection in children and adolescents with household contact with adults with active pulmonary tuberculosis as assessed by tuberculin skin test and interferon-gamma release assays en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Diagnost Imaging, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Diagnost Imaging, Sao Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP: 2009/07603-7
dc.identifier.doi 10.1017/S0950268815001727
dc.description.source Web of Science
dc.identifier.wos WOS:000369712100007
dc.coverage New York
dc.citation.volume 144
dc.citation.issue 4



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