Rate of tuberculosis infection in children and adolescents with household contact with adults with active pulmonary tuberculosis as assessed by tuberculin skin test and interferon-gamma release assays

Rate of tuberculosis infection in children and adolescents with household contact with adults with active pulmonary tuberculosis as assessed by tuberculin skin test and interferon-gamma release assays

Author Ferrarini, M. A. G. Autor UNIFESP Google Scholar
Spina, F. G. Autor UNIFESP Google Scholar
Weckx, L. Y. Autor UNIFESP Google Scholar
Lederman, H. M. Autor UNIFESP Google Scholar
De Moraes-Pinto, M. I. Autor UNIFESP Google Scholar
Abstract Tuberculosis (TB) infection was evaluated in Brazilian immunocompetent children and adolescents exposed and unexposed (control group) to adults with active pulmonary TB. Both groups were analysed by clinical and radiological assessment, TST, QFT-IT and T-SPOT. TB. The three tests were repeated after 8 weeks in the TB-exposed group if results were initially negative. Individuals with latent tuberculosis infection (LTBI) were treated and tests were repeated after treatment. Fifty-nine TB-exposed and 42 controls were evaluated. Rate of infection was 69.5% and 9.5% for the exposed and control groups, respectively. The exposed group infection rate was 61% assessed by TST, 57.6% by T-SPOT. TB, and 59.3%, by QFT-IT. No active TB was diagnosed. Agreement between the three tests was 83.1% and 92.8% in the exposed and control groups, respectively. In the exposed group, T-SPOT. TB added four TB diagnoses [16%, 95% confidence interval (CI) 1.6-30.4] and QFT-IT added three TB diagnoses (12%, 95% CI 0-24.7) in 25 individuals with negative tuberculin skin test (TST). Risk factors associated to TB infection were contact with an adult with active TB [0-60 days: odds ratio (OR) 6.9; >60 days: OR 27.0] and sleeping in the same room as an adult with active TB (OR 5.2). In Brazilian immunocompetent children and adolescents, TST had a similar performance to interferon-gamma release assays and detected a high rate of LTBI.
Keywords Adolescents
BCG
children
IGRA
latent tuberculosis infection
TST
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil
Grant number FAPESP: 2009/07603-7
Date 2016
Published in Epidemiology And Infection. New York, v. 144, n. 4, p. 712-723, 2016.
ISSN 0950-2688 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 712-723
Origin http://dx.doi.org/10.1017/S0950268815001727
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000369712100007
URI https://repositorio.unifesp.br/handle/11600/57937

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