Detection of Cerebral Vasculopathy by Transcranial Doppler in Children With Neurofibromatosis Type 1

Detection of Cerebral Vasculopathy by Transcranial Doppler in Children With Neurofibromatosis Type 1

Author Sagica Fernandes Paschoal, Joelma Karin Autor UNIFESP Google Scholar
Paschoal, Fernando Mendes, Jr. Google Scholar
de Lima, Fernanda Teresa Autor UNIFESP Google Scholar
Pinho, Ricardo Silva Autor UNIFESP Google Scholar
Pereira Vilanova, Luiz Celso Autor UNIFESP Google Scholar
Bor-Seng-Shu, Edson Google Scholar
Masruha, Marcelo Rodrigues Autor UNIFESP Google Scholar
Abstract Neurofibromatosis type 1 is characterized by nerve sheath neurofibromas associated with a number of additional clinical features, including cerebrovascular disease. The aim of this study was to use transcranial Doppler as a screening method for identifying cerebral vasculopathy in children with neurofibromatosis type 1. Forty children with neurofibromatosis type 1, aged 5 to 18 years old, were examined by transcranial Doppler. Patients presenting with hemodynamic features of arterial stenosis/occlusion on transcranial Doppler underwent magnetic resonance angiography to confirm the findings. Magnetic resonance angiography was performed on 4 children who exhibited a transcranial Doppler hemodynamic pattern indicative of cerebral vasculopathy. Among these cases, 2 presented internal carotid artery stenosis/occlusion, 1 had bilateral middle cerebral artery stenosis, and 1 presented a normal magnetic resonance angiography result. Transcranial Doppler can be used routinely in the investigation of cerebrovascular disease in neurofibromatosis type 1 patients, where magnetic resonance angiography can be subsequently applied to confirm the diagnosis, further contributing to the prevention of cerebrovascular events.
Keywords transcranial Doppler
cerebrovascular disease
xmlui.dri2xhtml.METS-1.0.item-coverage Thousand Oaks
Language English
Date 2016
Published in Journal Of Child Neurology. Thousand Oaks, v. 31, n. 3, p. 351-356, 2016.
ISSN 0883-0738 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Inc
Extent 351-356
Access rights Closed access
Type Article
Web of Science ID WOS:000370429700013

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