Proteomic profile of seminal plasma in adolescents and adults with treated and untreated varicocele

Proteomic profile of seminal plasma in adolescents and adults with treated and untreated varicocele

Author Camargo, Mariana Autor UNIFESP Google Scholar
Intasqui, Paula Autor UNIFESP Google Scholar
Bertolla, Ricardo Pimenta Autor UNIFESP Google Scholar
Abstract Varicocele, the most important treatable cause of male infertility, is present in 15% of adult males, 35% of men with primary infertility, and 80% of men with secondary infertility. On the other hand, 80% of these men will not present infertility. Therefore, there is a need to differentiate a varicocele that is exerting a deleterious effect that is treatable from a "silent" varicocele. Despite the growing evidence of the cellular effects of varicocele, its underlying molecular mechanisms are still eluding. Proteomics has become a promising area to determine the reproductive biology of semen as well as to improve diagnosis of male infertility. This review aims to discuss the state-of-art in seminal plasma proteomics in patients with varicocele to discuss the challenges in undertaking these studies, as well as the future outlook derived from the growing body of evidence on the seminal proteome.
Keywords male infertility
proteomics
seminal plasma
varicocele
varicocelectomy
xmlui.dri2xhtml.METS-1.0.item-coverage Mumbai
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
National Council for Scientific and Technological Development (CNPq)
Grant number FAPESP: 2012/15039-7
FAPESP: 2014/11493-0
FAPESP: 2014/17185-6
CNPq: 306616/2013-0
Date 2016
Published in Asian Journal Of Andrology. Mumbai, v. 18, n. 2, p. 194-201, 2016.
ISSN 1008-682X (Sherpa/Romeo, impact factor)
Publisher Medknow Publications & Media Pvt Ltd
Extent 194-201
Origin http://dx.doi.org/10.4103/1008-682X.168788
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000370293900008
URI https://repositorio.unifesp.br/handle/11600/57925

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