Thoracic lymphadenopathy in benign diseases: A state of the art review

Thoracic lymphadenopathy in benign diseases: A state of the art review

Author Nin, Carlos Schueler Google Scholar
Silveira de Souza, Vinicius Valerio Google Scholar
do Amaral, Ricardo Holderbaum Google Scholar
Schuhmacher Neto, Roberto Google Scholar
Tronco Alves, Giordano Rafael Google Scholar
Marchiori, Edson Google Scholar
Irion, Klaus Loureiro Google Scholar
Balbinot, Fernanda Google Scholar
Portes Meirelles, Gustavo de Souza Autor UNIFESP Google Scholar
Santana, Pablo Google Scholar
Portugal Gomes, Antonio Carlos Google Scholar
Hochhegger, Bruno Google Scholar
Abstract Lymphadenopathy is a common radiological finding in many thoracic diseases and may be caused by a variety of infectious, inflammatory, and neoplastic conditions. This review aims to describe the patterns of mediastinal and hilar lymphadenopathy found in benign diseases in immunocompetent patients. Computed tomography is the method of choice for the evaluation of lymphadenopathy, as it is able to demonstrate increased size of individual nodes, abnormalities of the interface between the mediastinum and lung, invasion of surrounding fat, coalescence of adjacent nodes, obliteration of the mediastinal fat, and hypo- and hyperdensity in lymph nodes. Intravenous contrast enhancement may be needed to help distinguish nodes from vessels. The most frequent infections resulting in this finding are tuberculosis and fungal disease (particularly histoplasmosis and coccidioidomycosis). Sarcoidosis is a relatively frequent cause of lymphadenopathy in young adults, and can be distinguished from other diseases - especially when enlarged lymph nodes are found to be multiple and symmetrical. Other conditions discussed in this review are silicosis, drug reactions, amyloidosis, heart failure, Castleman's disease, viral infections, and chronic obstructive pulmonary disease. (C) 2016 Elsevier Ltd. All rights reserved.
Keywords Lymphadenopathy
Thoracic disease
Benign disease
Computed tomography
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Date 2016
Published in Respiratory Medicine. London, v. 112, p. 10-17, 2016.
ISSN 0954-6111 (Sherpa/Romeo, impact factor)
Publisher W B Saunders Co Ltd
Extent 10-17
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000371096800002

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