Posterior Circulation Evaluation in Patients with Sickle Cell Anemia

Posterior Circulation Evaluation in Patients with Sickle Cell Anemia

Author Adegoke, Samuel Ademola Autor UNIFESP Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Vicari, Perla Autor UNIFESP Google Scholar
Carrete, Henrique, Jr. Autor UNIFESP Google Scholar
Idagawa, Marcos Hideki Autor UNIFESP Google Scholar
Massaro, Ayrton Roberto Google Scholar
Silva, Gisele Sampaio Autor UNIFESP Google Scholar
Abstract Background: The role of transcranial Doppler (TCD) ultrasonography in identifying children with sickle cell anemia (SCA) at risk for stroke is well known; however, the major studies that evaluated TCD velocities in children with SCA did not report posterior circulation evaluation data. The objective of our study was to describe the pattern of blood flow velocities in the posterior circulation of patients with SCA and to examine their relationship with findings on magnetic resonance imaging (MRI)/magnetic resonance angiography (MRA). Methods: All adult patients with SCA followed in the outpatient clinic of our hospital were evaluated with TCD and MRI/MRA. The highest velocities of the middle cerebral arteries or internal carotid arteries were taken as the time-averaged maximum mean (TAMM) velocity for each patient and the maximum mean flow velocities in the posterior circulation (TAMMpost) were recorded. Results: Fifty-six patients with SCA and 56 healthy nonanemic volunteers were evaluated. The mean TAMMpost in the basilar, vertebral, and posterior cerebral arteries (PCAs) were significantly higher among cases than controls (P < .01). In patients with SCA, the TAMMpost in all posterior circulation arteries had a positive correlation with TAMM. Only 1 patient with stenosis in the posterior circulation (right PCA) was identified. Conclusion: We found a low frequency of stenosis but high blood flow velocities in the posterior circulation in patients with SCA. The role of increased TCD velocities in the posterior circulation upon stroke risk in patients with SCA should be further examined.
Keywords Sickle cell anemia
transcranial Doppler
posterior circulation
magnetic resonance imaging
intracranial stenoses
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Date 2016
Published in Journal Of Stroke & Cerebrovascular Diseases. Amsterdam, v. 25, n. 3, p. 717-721, 2016.
ISSN 1052-3057 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 717-721
Access rights Closed access
Type Article
Web of Science ID WOS:000371175900037

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