Schinus terebinthifolius administration prevented behavioral and biochemical alterations in a rotenone model of Parkinson's disease

Schinus terebinthifolius administration prevented behavioral and biochemical alterations in a rotenone model of Parkinson's disease

Author Sereniki, Adriana Google Scholar
Linard-Medeiros, Cybelle F. B. Google Scholar
Silva, Shirliane N. Google Scholar
Silva, Juciene B. R. Google Scholar
Peixoto Sobrinho, Tadeu J. S. Google Scholar
da Silva, Juliano R. Google Scholar
Alves, Lariza D. S. Google Scholar
Smaili, Soraya S. Autor UNIFESP Google Scholar
Wanderley, Almir G. Google Scholar
Lafayette, Simone S. L. Google Scholar
Abstract Parkinson's disease is a neurodegenerative disorder characterized by motor impairment, cognitive decline and psychiatric symptoms. Schinus terebinthifolius Raddi, Anacardiaceae, had been studied for its anti-inflammatory and antioxidant properties, and in this study, the stem bark was evaluated for the neuroprotective effects on behavioral and biochemical alterations induced by administrations of rotenone in rats. Behavioral evaluations were performed using open-field and rotarod. The in vitro and in vivo antioxidant activities were determined by the DPPH radical scavenging activity and lipid peroxidation method respectively. The administration of rotenone (3 mg/kg, s.c.) produced hypolocomotion, increase of immobility and muscle incoordination, while the treatment with S. terebinthifolius stem bark extract (150, 300 and 600 mg/kg p.o.) for seven days prevented rotenone-induced dysfunctional behavior. Biochemical analysis of the substantia nigra, striatum and cortex revealed that rotenone administration significantly increased lipid peroxidation, which was inhibited by treatment with all doses of S. terebinthifolius. The results suggested neuroprotective effect of S. terebinthifolius possibly mediated through its antioxidant activity, indicating a potential therapeutic benefit of this species in the treatment of Parkinson's disease. (C) 2015 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.
Keywords Antioxidant effects
Lipidic peroxidation
Parkinson's disease
Rotenone
Schinus terebinthifolius
xmlui.dri2xhtml.METS-1.0.item-coverage Curitiba-Pr
Language English
Sponsor CAPES
Date 2016
Published in Revista Brasileira De Farmacognosia-Brazilian Journal Of Pharmacognosy. Curitiba-Pr, v. 26, n. 2, p. 240-245, 2016.
ISSN 0102-695X (Sherpa/Romeo, impact factor)
Publisher Soc Brasileira Farmacognosia
Extent 240-245
Origin http://dx.doi.org/10.1016/j.bjp.2015.11.005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000372594400014
SciELO ID S0102-695X2016000200240 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/57879

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