Period of Hyperbaric Oxygen Delivery Leads to Different Degrees of Hepatic Ischemia/Reperfusion Injury in Rats

Period of Hyperbaric Oxygen Delivery Leads to Different Degrees of Hepatic Ischemia/Reperfusion Injury in Rats

Author Chaves, J. C. Google Scholar
Neto, F. S. Google Scholar
Ikejiri, A. T. Google Scholar
Bertoletto, P. R. Google Scholar
Teruya, R. Google Scholar
Santos Simoes, R. Autor UNIFESP Google Scholar
Tikazawa, E. H. Google Scholar
Liu, J. B. Google Scholar
Carrara, F. L. Google Scholar
Taha, M. O. Autor UNIFESP Google Scholar
Fagundes, D. J. Autor UNIFESP Google Scholar
Abstract Background. This study evaluated the morphology of the rat liver when hyperbaric oxygen (HBO) was used at various stages of ischemia and reperfusion. Methods. Thirty-two male Wistar rats, subjected to 30 minutes of hepatic ischemia and 30 minutes of reperfusion, were randomly assigned as follows: GIR (n = 8), control without HBO; GHBO/I (n = 8), in which HBO was applied only during ischemia; GHBO/R (n = 8), HBO only during reperfusion; and GHBO/IR (n = 8), HBO during both ischemia and reperfusion. Feasibility scores of hepatocytes were determined by assessing 8 items related to liver injury. Results. The histologic injury score of the hepatic specimens was significantly lower in the GHBO/I group (79.0 +/- 0.1) compared with the GIR group (135.0 +/- 0.1). HBO was not effective when applied during reperfusion (GHBO/R, 151.3 +/- 0.1) or during the ischemia plus reperfusion period (GHBO/IR, 131.0 +/- 0.1). The sum was significantly higher (P < .05) in HBO-treated animals during the reperfusion period (ie, in the GHBO/R group compared with any of the other groups). Conclusions. A favorable effect was obtained when HBO was administered early during ischemia. HBO given in later periods of reperfusion was associated with a more severe sum index percentage of liver damage.
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Date 2016
Published in Transplantation Proceedings. New York, v. 48, n. 2, p. 516-520, 2016.
ISSN 0041-1345 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 516-520
Access rights Closed access
Type Article
Web of Science ID WOS:000375240300053

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