Anthocyanins as inflammatory modulators and the role of the gut microbiota

Anthocyanins as inflammatory modulators and the role of the gut microbiota

Author Morais, Carina Almeida Autor UNIFESP Google Scholar
de Rosso, Veridiana Vera Autor UNIFESP Google Scholar
Estadella, Debora Autor UNIFESP Google Scholar
Pisani, Luciana Pellegrini Autor UNIFESP Google Scholar
Abstract The health benefits of consuming fruits that are rich in polyphenols, especially anthocyanins, have been the focus of recent in vitro and in vivo investigations. Thus, greater attention is being directed to the reduction of the inflammatory process associated with the intestinal microbiota and the mechanism underlying these effects because the microbiota has been closely associated with the metabolism of these compounds in the gastrointestinal tract. Further interest lies in the ability of these metabolites to modulate the growth of specific intestinal bacteria. Thus, this review examines studies involving the action of the anthocyanins that are present in many fruits and their effect in the modulating the inflammatory process associated with the interaction between the host and the gut microbiota. The findings of both in vitro and in vivo studies suggest a potential antiinflammatory effect of these compounds, which seem to inhibit activation of the signaling pathway mediated by the transcription factor NF kappa B. This effect is associated with modulation of a beneficial gut microbiota, particularly an increase in Bifidobacterium strains. (C) 2015 Elsevier Inc. All rights reserved.
Keywords Anthocyanin
NF kappa B
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Grant number FAPESP: 2013/25101-4
Date 2016
Published in Journal Of Nutritional Biochemistry. New York, v. 33, p. 1-7, 2016.
ISSN 0955-2863 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 1-7
Access rights Closed access
Type Article
Web of Science ID WOS:000378011400001

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account