The effect of low-level laser therapy on oxidative stress and functional fitness in aged rats subjected to swimming: an aerobic exercise

The effect of low-level laser therapy on oxidative stress and functional fitness in aged rats subjected to swimming: an aerobic exercise

Author Guaraldo, Simone A. Google Scholar
Serra, Andrey Jorge Google Scholar
Amadio, Eliane Martins Google Scholar
Antonio, Ednei Luis Autor UNIFESP Google Scholar
Silva, Flavio Autor UNIFESP Google Scholar
Portes, Leslie Andrews Autor UNIFESP Google Scholar
Ferreira Tucci, Paulo Jose Autor UNIFESP Google Scholar
Pinto Leal-Junior, Ernesto Cesar Google Scholar
Camillo de Carvalho, Paulo de Tarso Google Scholar
Abstract The aim of the present study was to determine whether low-level laser therapy (LLLT) in conjunction with aerobic training interferes with oxidative stress, thereby influencing the performance of old rats participating in swimming. Thirty Wistar rats (Norvegicus albinus) (24 aged and six young) were tested. The older animals were randomly divided into aged-control, aged-exercise, aged-LLLT, aged-LLLT/exercise, and young-control. Aerobic capacity (VO2max0.75) was analyzed before and after the training period. The exercise groups were trained for 6 weeks, and the LLLT was applied at 808 nm and 4 J energy. The rats were euthanized, and muscle tissue was collected to analyze the index of lipid peroxidation thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activities. VO(2)(0.75)max values in the aged-LLLT/exercise group were significantly higher from those in the baseline older group (p < 0.01) and the LLLT and exercise group (p < 0.05). The results indicate that the activities of CAT, SOD, and GPx were higher and statistically significant (p < 0.05) in the LLLT/exercise group than those in the LLLT and exercise groups. Young animals presented lesser and statistically significant activities of antioxidant enzymes compared to the aged group. The LLLT/exercise group and the LLLT and exercise group could also mitigate the concentration of TBARS (p > 0.05). Laser therapy in conjunction with aerobic training may reduce oxidative stress, as well as increase VO(2)(0.75)max, indicating that an aerobic exercise such as swimming increases speed and improves performance in aged animals treated with LLLT.
Keywords Low-level laser
Aerobic exercise
Oxidative stress
Aged
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor Brazilian Research Council-CNPq
Grant number CNPq: 307665/2012-7
Date 2016
Published in Lasers In Medical Science. London, v. 31, n. 5, p. 833-840, 2016.
ISSN 0268-8921 (Sherpa/Romeo, impact factor)
Publisher Springer London Ltd
Extent 833-840
Origin http://dx.doi.org/10.1007/s10103-016-1882-2
Access rights Closed access
Type Article
Web of Science ID WOS:000378543200003
URI https://repositorio.unifesp.br/handle/11600/57688

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